100933-54-8

Basic information

• Product Name: bromo-2 butyl-4 pyridine
• Synonyms: bromo-2 butyl-4 pyridine
• CAS NO: 100933-54-8
• Molecular Weight: 214.105
• Mol File: 100933-54-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: bromo-2 butyl-4 pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: bromo-2 butyl-4 pyridine(100933-54-8)
• EPA Substance Registry System: bromo-2 butyl-4 pyridine(100933-54-8)

Safety Data

• Hazardous Substances Data: 100933-54-8(Hazardous Substances Data)

Upstream product

• 13534-89-9 2,3-dibromopyridine 
• 109-72-8 n-butyllithium 

Downstream Products

• 317861-31-7 4-aminomethyl-N-[1-(4-butyl-pyridin-2-yl)-2-cyclohexyl-ethyl]-benzamide 
• 317861-29-3 5-Amino-pentanoic acid [(S)-1-(4-butyl-pyridin-2-yl)-2-cyclohexyl-ethyl]-amide 
• 83282-39-7 4-butyl-pyridine-2-carboxylic acid 

Relevant articles and documents

ACTION DU N-BUTYLLITHIUM SUR LES BROMO-3 HALOGENO-2 PYRIDINES FLUOREE, CHLOREE ET BROMEE PRINCIPE ET ETUDE D'UNE POSSIBILITE REACTIONNELLE NOUVELLE: L'HOMOTRANSMETALLATION

Apart from the common bromine-lithium exchange reaction in brominated aromatic compounds, it is possible to obtain a lithio-derivative quite different from the one usually described in such a reaction.This new reaction, which results from a special experimental condition is called 'homotransmetalation', and it occurs when using n-buthyllithium and 3-bromo 2-halogenopyridines (1).Different behaviour is observed with the three similar compounds (1:X = F,Cl,Br).Explanations are proposed of these results.It is then possible to compare the relative stabilities of the proposed lithio-structures.It is evident that nucleophilic substitution of bromine in position 4 of the pyridine ring is easier than is usually recognised.