10098-89-2Relevant articles and documents
A Water-Soluble Cationic Zinc Lysine Precursor for Coating ZnO on Biomaterial Surfaces
Yuan, Shaotang,Nawrocki, Shiri,Stranick, Michael,Yang, Ying,Zheng, Chong,Masters, James G.,Pan, Long
, p. 10094 - 10097 (2016)
A novel water-soluble cationic zinc lysine coordination compound, [Zn[(C6H14N2O2)]2Cl]Cl·2H2O (1), has been designed and synthesized and its crystal structure determined. The aqueous solution of this coordination compound is not only transparent and stable at room temperature but it is also nearly neutral (pH ～ 7). It is worth noting that zinc oxide (ZnO) forms in situ upon dilution of a solution of the compound. The bioactivity of ZnO has been confirmed using an Alarma Blue assay. These unique properties allow the coordination compound to gently grow ZnO coating with excellent antibacterial benefits onto biomaterial surfaces in a facile and safe manner.
Polyunsaturated fatty acid derivatives, pharmaceutical compositions containing the same, method for the preparation thereof, and their use as medicament
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, (2008/06/13)
The compounds of the Formula (I) STR1 wherein R1 is a C18-24 alkenyl containing at least two double bonds, or --(CH2)n --CH(NH2)m --COOH X is 0, NH or C1-4 alkyl-N, Y is CONH2, COOH or COOMe, wherein Me is hydrogen metal, and R2 is a side chain of a any amino acid except L-GLU or L-ASP at α-position or a group of Formula wherein k is zero or an integer of 1, n is zero or an integer of 1 to 3, m is zero or an integer of 1 to 4, A is hydroxyl or one A is hydroxyl and the other A is hydrogen. M is H or R1 --CO and X and R1 are as defined above and their salts having tyrosine kinase inhibitor activity can be used as antitumor agents.
Isolation and Properties of Lysine-producing Mutants with Feedback-resistant Aspartokinase Derived from a Brevibacterium flavum Strain with Citrate Synthase- and Pyruvate Kinase-defects and Feedback-resistant Phosphoenolpyruvate Carboxylase
Shiio, Isamu,Yoshino, Hiroshi,Sugimoto, Shin-ichi
, p. 3275 - 3282 (2007/10/02)
Although the growth of Brevibacterium flavum KH-21 with CSL, PK-, and PCR was resistant to a lysine analogue, AEC, plus Thr at a concentration of 1 to 3 g/l, used conventionally for isolation of AKR mutants, it was inhibited by higher concentrations of them, and recovered partially upon the addition of Lys, DAP and Met.The growth level recovered was equal to that in the presence of Thr alone.Several lysin-producing mutants with AKR were isolated as those resistant to these high concentrations of AEC plus Thr.The representative strain, AH-198, produced 51 g/l of Lys*HCl at maximum, when cultured for 72 hr in a medium containing 100 g/l glucose, while the parent strain KH-21 produced only 2 g/l.The productivity of strain AH-198 was the same as or a little higher than that of the HD- type lysine-producing strain No. 22 with CSL, PK-, and PCR.I0.5, the concentration of Lys and Thr inhibiting 50 percent of the AK activity was 40 mM, 267-fold that of the parent enzyme.The Km for Asp and the optimum concentration of (NH4)2SO4 for the apparent Vmax were also increased.In addition, the inhibition by Thr or Lys alone disappeared in the mutant enzyme.
