1009809-16-8

Basic information

• Product Name: C₁₈H₂₇N₃O₈
• Synonyms: C₁₈H₂₇N₃O₈
• CAS NO: 1009809-16-8
• Molecular Weight: 413.428
• Mol File: 1009809-16-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₇N₃O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₇N₃O₈(1009809-16-8)
• EPA Substance Registry System: C₁₈H₂₇N₃O₈(1009809-16-8)

Safety Data

• Hazardous Substances Data: 1009809-16-8(Hazardous Substances Data)

Upstream product

• 28179-47-7 5-aminoisophthalic acid monomethyl ester 
• 40137-22-2 3-methylamino-propane-1,2-diol 

Downstream Products

• 73334-07-3 iopromide 

Relevant articles and documents

Preparation method of iopromide

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of iopromide. The method comprises the following steps: (1) chloridizing 5-methylaminoisophthalic acid monomethyl ester as shown in a formula II and used as a raw material to obtain 3-amino-5-chloroformylbenzoate as shown in a formula III; (2) enabling reaction between the compoundas shown in the formula III and methoxyacetyl chloride to obtain 3-chloroformyl 5-[methoxyacetyl)amino)]-methyl benzoate as shown in a formula IV; (3) enabling reaction between the compound as shown in the formula IV and 3-aminopropanediol to obtain 3-[(2,3-dihydroxypropylaminoformyl)-5-[(methoxyacetyl)amino]-methyl benzoate as shown in a formula V; (4) enabling reaction between the compound as shown in the formula V and 3-methylamino propanediol to obtain N,N'-di(2,3-dihydroxyl)-5-[(methoxyacetyl)amino)]-N-methyl-1,3-phthalamide as shown in a formula VI; and (5) enabling reaction between thecompound as shown in the formula VI and NaICl2 to obtain the iopromide. The preparation method of the iopromide provided by the invention is low in production cost, high in reproducibility and high inyield.