1010-70-4

Basic information

• Product Name: 3-hydroxy-2-methylquinazolin-4(3H)-one
• Synonyms: 4(3H)-quinazolinone, 3-hydroxy-2-methyl-
• CAS NO: 1010-70-4
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.172
• Mol File: 1010-70-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 364.6°C at 760 mmHg
• Flash Point: 174.3°C
• Density: 1.35g/cm³
• Vapor Pressure: 5.91E-06mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 3-hydroxy-2-methylquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2-methylquinazolin-4(3H)-one(1010-70-4)
• EPA Substance Registry System: 3-hydroxy-2-methylquinazolin-4(3H)-one(1010-70-4)

Safety Data

• Hazardous Substances Data: 1010-70-4(Hazardous Substances Data)

Usage

General Description

3-hydroxy-2-methylquinazolin-4(3H)-one is a chemical compound that belongs to the class of quinazolinone derivatives. It is a white to off-white crystalline powder that is commonly used in pharmaceutical research and development. 3-hydroxy-2-methylquinazolin-4(3H)-one has potential biological activities, including antiviral, anticancer, and anti-inflammatory properties, making it a target for drug discovery and development. Its molecular structure consists of a quinazoline ring with a hydroxyl group and a methyl group, and it has a molecular weight of 179.18 g/mol. 3-hydroxy-2-methylquinazolin-4(3H)-one has been studied for its potential therapeutic applications, and its structure serves as a basis for the design of new drugs with improved bioactivity and pharmacological properties.

Upstream product

• 2719-08-6 methyl 2-(acetylamino)benzoate 
• 622-33-3 N-benzyloxyamine 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 75-36-5 acetyl chloride 
• 112484-56-7 3-hydroxy-2,2-dimethyl-1,2-dihydroquinozalin-4-one 
• 67718-42-7 O-(2-aminobenzoyl) hydroxylamine 
• 78-39-7 Triethyl orthoacetate 
• 108-24-7 acetic anhydride 
• 5623-04-1 anthranilic hydroxamic acid 
• 4797-75-5 2-amino-N-(benzyloxy)benzamide 

Downstream Products

• 4765-41-7 3-benzyloxy-2-methyl-4-quinazolone 

Relevant articles and documents

Synthesis and application of N-hydroxylamine derivatives as potential replacements for HOBt

Several heterocycles containing N-hydroxylamine were prepared and tested as coupling additives to replace the use of N-hydroxybenzolriazole (HOBt.) derivatives. On the basis of our results on coupling yield and racemization-suppressing properties, we propose N-hydroxyindolin-2-one and 6- cfiloro-N-hydroxy-2-phenylbenzimidazole as suitable substitutes for HOBt. Wiley-VCH Verlag GmbH & Co. KGaA.

Fragment-based lead discovery: Screening and optimizing fragments for thermolysin inhibition

Fragment-based drug discovery has gained a foothold in today's lead identification processes. We present the application of in silico fragment-based screening for the discovery of novel lead compounds for the metalloendoproteinase thermolysin. We have chosen thermolysin to validate our screening approach as it is a well-studied enzyme and serves as a model system for other proteases. A protein-targeted virtual library was designed and screening was carried out using the program AutoDock. Two fragment hits could be identified. For one of them, the crystal structure in complex with thermolysin is presented. This compound was selected for structure-based optimization of binding affinity and improvement of ligand efficiency, while concomitantly keeping the fragment-like properties of the initial hit. Redesigning the zinc coordination group revealed a novel class of fragments possessing Ki values as low as 128 μm, thus they provide a good starting point for further hit evolution in a tailored lead design.

Synthesis of new fused hetecrocyclic compounds of benzpyrid-4-one derivatives and their some biological activity

A series of fused pyrazolino-, Isoxazolino-, Pyrimidino-, Pyrimidinothino-, thiazolidinones and β-lactam incorporating benzpyrid-4-one derivatives have been synthesized by different methods of chemical reaction. The prepared compounds were established by universals and modern methods of physical and chemical confirmation.