101345-72-6

Basic information

• Product Name: N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide
• Synonyms: N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide
• CAS NO: 101345-72-6
• Molecular Weight: 404.549
• Mol File: 101345-72-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide(101345-72-6)
• EPA Substance Registry System: N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide(101345-72-6)

Safety Data

• Hazardous Substances Data: 101345-72-6(Hazardous Substances Data)

Upstream product

• 101365-85-9 1-benzyl-3-methyl-4-[N-(2-fluorophenyl)-2-methoxypropionamido]piperidine 
• 19995-38-1 2-(thien-2-yl)ethyl chloride 
• 101365-86-0 N-(2-Fluoro-phenyl)-2-methoxy-N-((3S,4R)-3-methyl-piperidin-4-yl)-propionamide 
• 101365-85-9 N-((3R,4R)-1-Benzyl-3-methyl-piperidin-4-yl)-N-(2-fluoro-phenyl)-2-methoxy-propionamide 
• 101365-80-4 trans-1-benzyl-3-methyl-4-(2-fluoroanilino)piperidine 
• 34737-89-8 1-Benzyl-3-methyl-4-piperidon 
• 348-54-9 2-Fluoroaniline 
• 101365-86-0 N-(2-Fluoro-phenyl)-2-methoxy-N-((3R,4R)-3-methyl-piperidin-4-yl)-propionamide 

Relevant articles and documents

Synthesis and Pharmacological Evaluation of a Series of New 3-Methyl-1,4-disubstituted-piperidine Analgesics

The synthesis and intravenous analgesic activity of a series of 3-methyl-4-(N-phenyl amido)piperidines, entries 34-79, is described.The methoxyacetamide pharmacophore produced a series of compounds with optimal analgesic potency and short duration of action. cis-42 was 13 036 times more potent than morphine and 29 times more potent than fentanyl; however, the corresponding diastereomer 43 was only 2778 and 6 times more potent, respectively.Compounds 40, 43, 47, and 57 are extremely short acting; all had durations of action of about 2 min, which was about 1/5 of that of fentanyl in the mouse hot-plate test at a dose equivalent to 2 times the ED50 analgesic dose.Among the many compounds that displayed exceptional analgesic activity, duration of action was one of the main factors for choosing a candidate for further pharmacological investigation.At present, cis-1--3-methyl-4-2-fluorophenyl)methoxyacetamido>piperidine hydrochloride (40) (Anaquest, A-3331.HCl, Brifentanil) is in clinical evaluation.Opiate analgesics that possess short duration of action are excellent candidates for short surgical procedures in an outpatient setting where a rapid recovery is required.