1013625-20-1Relevant articles and documents
Structure-activity relationship for DNA topoisomerase II-induced DNA cleavage by azatoxin analogues
Madalengoitia, Jose S.,Tepe, Jetze J.,Werbovetz, Karl A.,Lehnert, Erich K.,Macdonald, Timothy L.
, p. 1807 - 1815 (1997)
Eighteen analogues of the nonintercalative DNA topoisomerase II (topo II)-active epipodophyllotoxin-ellipticine hybrid, azatoxin, were synthesized and evaluated for their ability to induce topo II-mediated DNA strand breaks in vitro. In general, the SAR p