1014717-75-9

Basic information

• Product Name: (S,Z)-tert-butyl(2-(5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethoxy)dimethylsilane
• Synonyms: (S,Z)-tert-butyl(2-(5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethoxy)dimethylsilane
• CAS NO: 1014717-75-9
• Molecular Weight: 382.734
• Mol File: 1014717-75-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S,Z)-tert-butyl(2-(5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethoxy)dimethylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: (S,Z)-tert-butyl(2-(5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethoxy)dimethylsilane(1014717-75-9)
• EPA Substance Registry System: (S,Z)-tert-butyl(2-(5-((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethoxy)dimethylsilane(1014717-75-9)

Safety Data

• Hazardous Substances Data: 1014717-75-9(Hazardous Substances Data)

Upstream product

• 50-14-6 Calciferol 
• 84985-78-4 (4R,7aR)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-4-((R,Z)-1-hydroxy-2-((S)-5-hydroxy-2-methylenecyclohexylidene)ethyl)-7a-methyloctahydro-1H-inden-4-ol 

Downstream Products

• 100858-27-3 (S)-(Z)-{2-[5-(tert-butyldimethylsiloxy)-2-methylenecyclohexylidene]ethyl}diphenylphosphine oxide 
• 651734-12-2 20S-Hydroxyvitamin D₃ 
• 123836-63-5 <3S-(1Z,3α,5β)>-<2-<3-Fluoro-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>ethyl>diphenylphosphine Oxide 
• 123836-62-4 <1R-(1β,3Z,5α)>-<<3-(2-Chloroethylidene)-5-fluoro-4-methylenecyclohexyl>oxy>(1,1-dimethylethyl)dimethylsilane 
• 123836-61-3 <3S-(1Z,3β,5α)>-<3-Fluoro-5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-methylenecyclohexylidene>ethanol 
• 1014718-14-9 C₃₇H₅₉⁽²⁾H₆FO₂Si₂ 
• 1014718-19-4 1α-tert-butyl-dimethyl-silanyloxy-3β-fluoro-25-trimethylsilanyloxy-16-ene-20-cyclopropyl-26,27-hexadeutero-cholecalciferol 
• 199798-99-7 C₃₈H₆₅FO₂Si₂ 
• 926315-13-1 benzoic acid (2R,3S,5R,7S)-7-((t-butyldimethyl)silanyloxy)-5-hydroxy-4-methylene-1-oxa-spiro[2.5]oct-2-yl methyl ester 
• 926315-20-0 benzoic acid (2R,3S,5S,7S)-7-((t-butyldimethyl)silanyloxy)-5-hydroxy-4-methylene-1-oxa-spiro[2.5]oct-2-yl methyl ester 
• 926315-15-3 benzoic acid 2-[(3S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-3-fluoro-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester 
• 1014717-86-2 C₄₅H₆₉⁽²⁾H₆F₇O₃Si₃ 
• 1014717-93-1 C₄₅H₆₉⁽²⁾H₆F₇O₃Si₃ 
• 1014717-90-8 C₄₅H₇₁⁽²⁾H₆F₇O₃Si₃ 

Relevant articles and documents

Total synthesis of biologically active 20S-hydroxyvitamin D3

A total synthetic strategy of 20S-hydroxyVitamin D3 [20S-(OH)D3] involving modified synthesis of key intermediates 7 and 12, Grignard reaction to stereoselectively generate 20S-OH and Wittig-Horner coupling to establish D3 framework, was completed in 16 steps with an overall yield of 0.4%. The synthetic 20S-(OH)D3 activated Vitamin D receptor (VDR) and initiated the expression of downstream genes. In addition, 20S-(OH)D3 showed similar inhibitory potency as calcitriol [1,25(OH)2D3] on proliferation of melanoma cells.