10161-34-9 Usage
Description
Trenbolone acetate (brand name: Revalor) is a 19-nortestosterone derivative and a synthetic, injected anabolic-androgenic steroid that is used in veterinary medicine. It is a highly efficient anabolic steroid that can greatly enhance the performance of athletes. Trenbolone acetate has several physiological effects. First, it can greatly promote insulin-like growth factor-1 (IGF-1). IGF-1 is a powerful and natural anabolic hormone that of great importance for muscle tissue development. Secondly, it can greatly increase the red blood cell count, further increasing blood oxygen and enhancing muscular endurance. Moreover, it can inhibit the glucocorticoid hormone, a hormone that destroy muscle tissue and promote fat. Finally, it can improve nutrient uptake and consumption efficiency.
Chemical Properties
Pale Yellow Solid
Uses
Different sources of media describe the Uses of 10161-34-9 differently. You can refer to the following data:
1. A steroid used to increase the muscle growth of livestock.
2. anti-cataract agent
Manufacturing Process
Stage A: Preparation of 17β-Benzoyloxy-Estra-4,9,11-Trien-3-one - 0.400 g of
17β-benzoyloxy-4,5-seco-estra-9,11-diene-3,5-dione is dissolved in 4 cc of
toluene under an inert atmosphere. The solution is cooled to 3°C, then 0.48
cc is added of the solution of sodium tert-amylate in anhydrous toluene,
diluted by the addition of a further 4.8 cc of anhydrous toluene.
This reaction mixture is kept between 0°C and +5°C for six hours, with
agitation and under an inert atmosphere, then 5 cc of a 0.2 N solution of
acetic acid in toluene are added. The mixture is extracted with toluene, and
the extracts are washed with water and evaporated to dryness. The residue is
taken up in ethyl acetate, and then the solution is evaporated to dryness in
vacuo, yielding a resin which is dissolved in methylene chloride, and the
solution passed through a column of 40 g of magnesium silicate. Elution is
carried out first with methylene chloride, then with methylene chloride
containing 0.5% of acetone, and 0.361 g is thus recovered of a crude product,
which is dissolved in 1.5 cc of isopropyl ether; then hot methanol is added
and the mixture left at 0°C for one night.
0.324 g of the desired 17β-benzoyloxy-estra-4,9,11-trien-3-one are thus
finally obtained, being a yield of 85%, melting point is 154°C.
Stage B: Preparation of 17β-Hydroxy-Estra-4,9,11-Trien-3-one - 3 g of 17β-
benzoyloxy-estra-4,9,11-trien-3-one, obtained as described in Stage A are
dissolved in 15 cc of methanol. 0.03 g of hydroquinone is added, and the
mixture is taken to reflux while bubbling in nitrogen. Then 1.2 cc of 11%
methanolic caustic potash is added and reflux is maintained for three hours,
after which the reaction product is acidified with 0.36 cc of acetic acid.
The methyl benzoate thus formed is eliminated by steam distillation, and
2.140 g of crude product are obtained, which are dissolved in 20 cc of
methylene chloride. This solution is passed through 10 parts of magnesium
silicate, elution being performed with 250 cc of methylene chloride containing
5% of acetone. After evaporation of the solvent 2.050 g of product is
recovered, which is recrystallized from isopropyl ether.
In this way 1.930 g of the desired 17β-hydroxy-estra-4,9,11-trien-3-one is
obtained being a yield of 89%, melting point is 186°C. It is converted to the
acetate by acetic anhydride.
References
https://en.wikipedia.org/wiki/Trenbolone_acetate
Henricks, D. M., et al. "Serum concentrations of trenbolone-17 beta and estradiol-17 beta and performance of heifers treated with trenbolone acetate, melengestrol acetate, or estradiol-17 beta." Journal of Animal Science 75.10(1997):2627-33.
https://www.steroid.com/trenbolone-acetate.php
Check Digit Verification of cas no
The CAS Registry Mumber 10161-34-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,6 and 1 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 10161-34:
(7*1)+(6*0)+(5*1)+(4*6)+(3*1)+(2*3)+(1*4)=49
49 % 10 = 9
So 10161-34-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H24O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h9-11,17-19H,3-8H2,1-2H3
