101620-09-1

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-
• CAS NO: 101620-09-1
• Molecular Formula: C29H31N3O2
• Molecular Weight: 453.584
• Mol File: 101620-09-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-(101620-09-1)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-(101620-09-1)

Safety Data

• Hazardous Substances Data: 101620-09-1(Hazardous Substances Data)

Usage

Molecular structure

The compound has an isoindole core with a piperazine moiety attached to a butyl chain, which is connected to a diphenylmethyl group.

Chemical class

It belongs to the class of isoindoles.

Potential pharmacological properties

The compound may have potential pharmacological properties, making it useful in medicinal chemistry research.

Application in drug development

It could be used in the development of new drugs targeting the central nervous system.

Unique structure and functional groups

The compound's unique structure and functional groups make it an interesting target for further investigation in drug design and development.

Upstream product

• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 841-77-0 diphenylmethylpiperazine 

Downstream Products

• 120301-48-6 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(3-trifluoromethyl-phenyl)-acrylamide 
• 101618-68-2 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(3,4-dimethoxy-phenyl)-acrylamide 
• 120301-59-9 N-<4-(4-diphenylmethyl-1-piperazinyl)butyl>-3-(3-quinolyl)acrylamide 
• 120301-58-8 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-quinolin-2-yl-acrylamide 
• 120301-60-2 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-quinolin-4-yl-acrylamide 
• 120301-51-1 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(3,4-dichloro-phenyl)-acrylamide 
• 120301-45-3 N-<4-(4-diphenylmethyl-1-piperazinyl)butyl>-3-(4-hydroxyphenyl)acrylamide 
• 120301-49-7 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(3-hydroxy-phenyl)-acrylamide 
• 120301-56-6 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-pyridin-4-yl-acrylamide 
• 120301-55-5 (E)-N-<4-(4-diphenylmethyl-1-piperazinyl)butyl>-3-(3-pyridyl)acrylamide 
• 120301-69-1 N-<4-(4-diphenylmethyl-1-piperazinyl)butyl>-3-(4-hydroxyphenyl)acrylamide maleate 
• 120301-50-0 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(3-phenoxy-phenyl)-acrylamide 
• 120301-46-4 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-biphenyl-4-yl-acrylamide 
• 120301-53-3 (E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-naphthalen-2-yl-acrylamide 

Relevant articles and documents

Synthesis, Structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds

We have previously shown that a "reversed chloroquine (RCQ)" molecule, composed of a chloroquine-like moiety and a resistance reversal-like moiety, can overcome chloroquine resistance in P. falciparum (Burgess, S. J.; Selzer, A.; Kelly, J. X.; Smilkstein, M. J.; Riscoe, M. K.; Peyton, D. H. J. Med. Chem. 2006, 49, 5623. Andrews, S.; Burgess, S. J.; Skaalrud, D.; Kelly, J. X.; Peyton, D. H. J. Med. Chem. 2010, 53, 916). Here, we present an investigation into the Structure-activity relationship of the RCQ structures, resulting in an orally active molecule with good in vitro and in vivo antimalarial activity. We also present evidence of the mode of action, indicating that the RCQ molecules inhibit hemozoin formation in the parasite's digestive vacuole in a manner similar to that of chloroquine.

THIAZOLIDINECARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR THERAPEUTIC USES

Thiazolidinecarboxylic acid amides having combined antiallergic and antiasthmatic activities with an antagonist activity against platelet Activating Factor and having the following general formula (I) STR1