1017241-34-7

Basic information

• Product Name: Olanzapine LactaM IMpurity
• Synonyms: Olanzapine LactaM IMpurity;(3Z)-1,3-Dihydro-4-(4-Methyl-1-piperazinyl)-3-(2-oxopropylidene)-2H-1,5-benzodiazepin-2-one;Olanzapine LactuM;Olanzapine LactaM;Olanzapine KetolactaM;Olanzapine Impurity 10;Olanzapine Impurity J
• CAS NO: 1017241-34-7
• Molecular Formula: C17H20N4O2
• Molecular Weight: 312.3663
• Product Categories: Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1017241-34-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 188-191°C
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sligh
• PKA: 10.45±0.40(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Olanzapine LactaM IMpurity(CAS DataBase Reference)
• NIST Chemistry Reference: Olanzapine LactaM IMpurity(1017241-34-7)
• EPA Substance Registry System: Olanzapine LactaM IMpurity(1017241-34-7)

Safety Data

• Hazardous Substances Data: 1017241-34-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

A degradation product of Olanzapine (LY170053) (O253750) in solid oral formulations.

Synthetic route

4-Phenyl-1,2,4-triazolidine-3,5-dione (4233-33-4) + zyprexa (132539-06-1) → C17H20N4O2 (1017241-34-7)

Conditions	Yield
Stage #1: 4-Phenyl-1,2,4-triazolidine-3,5-dione; zyprexa In ethyl acetate at 20 - 25℃; for 0.166667h; Stage #2: With trifluoroacetic acid In ethyl acetate at 20℃; for 5h; Further stages.;

Upstream product

• 4233-33-4 4-Phenyl-1,2,4-triazolidine-3,5-dione 
• 132539-06-1 zyprexa 

Relevant articles and documents

Isolation, identification, and synthesis of two oxidative degradation products of olanzapine (LY170053) in solid oral formulations

Two impurities found in both stressed and aged solid-state formulations of olanzapine have been identified as (Z)-1,3-dihydro-4-(4-methyl-1-piperazinyl)-2- (2-oxopropylidene)-2H-1,5-benzodiazepin-2-one (1) and (Z)-1-[1,2-dihydro-4-(4- methyl-1-piperazinyl)-2-thioxo-3H-1,5-benzodiazepin-3-ylidene]propan-2-one (2). The structures indicate that the two impurities are degradation products resulting from oxidation of the thiophene ring of olanzapine. The impurities were isolated by preparative HPLC from a thermally stressed formulation, and characterized by UV, IR, MS, and NMR. A synthetic preparation of compounds 1 and 2 by reaction of olanzapine with the singlet oxygen mimic 4-phenyl-1,2,4- triazoline-3,5-dione (PTAD) is presented. The structure of 2 was also determined by single-crystal X-ray diffraction analysis. A degradation pathway for the formation of 1 and 2 is proposed.