101760-53-6Relevant articles and documents
Folate Analogues. 25. Synthesis and Biological Evaluation of N10-Propargylfolic Acid and Its Reduced Derivatives
Ghazala, Maryam,Nair, M. G.,Toghiyani, Tahereh R.,Kisliuk, R. L.,Gaumont, Y.,Kalman, T. I.
, p. 1263 - 1269 (2007/10/02)
N10-Propargylfolic acid (2), which is the closest pteridine analogue of the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (PDDF), was synthesized starting from diethyl -L-glutamate (5