1018-71-9 Usage
Description
PYRROLNITRIN, also known as a chloro-nitro-pyrrole, is a chemical compound belonging to the class of pyrroles. It is characterized by the presence of chloro and 3-chloro-2-nitrophenyl substituents at positions 3 and 4, respectively. This unique structure endows PYRROLNITRIN with various applications across different industries.
Uses
Used in Antifungal Applications:
PYRROLNITRIN is used as an antifungal agent for its ability to inhibit the growth and proliferation of fungi, making it a valuable component in the development of antifungal products.
Used in Microbiology:
PYRROLNITRIN from Pseudomonas cepacia has been utilized as a standard in the detection of pyrrolnitrin in Serratia marcescens cell culture extract. This application highlights its importance in the field of microbiology for accurate identification and analysis of specific bacterial strains.
Biochem/physiol Actions
Pyrrolnitrin blocks the terminal electron transport between succinate or reduced NADH and coenzyme Q. In mitochondria preparations of S. cerevisiae, the antibiotic inhibited succinate oxidase, NADH oxidase, succinate cythochrome C reductase, and NADH-cytochrome C reductase. Pyrrolnitrin is involved in many cellular processes such as oxidative stress, electron transport, DNA and RNA synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 1018-71-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,1 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1018-71:
(6*1)+(5*0)+(4*1)+(3*8)+(2*7)+(1*1)=49
49 % 10 = 9
So 1018-71-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H6Cl2N2O2/c11-8-3-1-2-6(10(8)14(15)16)7-4-13-5-9(7)12/h1-5,13H
1018-71-9Relevant articles and documents
Mechanistic studies on the conversion of arylamines into arylnitro compounds by aminopyrrolnitrin oxygenase: identification of intermediates and kinetic studies
Lee, Jungkul,Zhao, Huimin
, p. 622 - 625 (2006)
(Chemical Equation Presented) Rieske business! The Rieske N-oxygenase, aminopyrrolnitrin oxygenase (PrnD), catalyzes the unusual oxidation of arylamines to arylnitro compounds. Kinetic analysis has confirmed that PrnD catalyzes the conversion of the substrate pABA (4-aminobenzylamine) through at least three consecutive reactions: two monooxygenation steps and one dehydrogenation step (see scheme).
Antifungal compositions
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, (2008/06/13)
This invention relates to an antimycotic composition comprising pyrrolnitrin and at least one member selected from the group consisting of lanoconazole, butenafine or a salt thereof, and an allylamine-series antimycotic agent as active ingredients, which composition has a potent antimycotic action as compared with its component drugs used each independently and is not only of great use in the treatment of dermatophytosis such as tinea,tinea imbricata, tinea favosa, tinea profunda,etc. and fungal infections such as candidiasis ofcutaneous mucosa, candidiasis profunda,etc. but also useful from the standpoint of alleviation of side effects and improvement in the patient's compliance.
Bildung von Pyrrolnitrin und 3-(2-Amino-3-chlorphenyl)pyrrol aus 7-Chlortryptophan
Pee, Karl-Heinz van,Salcher, Olga,Lingens, Franz
, p. 855 - 856 (2007/10/02)
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