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101831-37-2

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101831-37-2 Usage

Description

Diclazuril (molecular formula: C17H9Cl3N4O2, Trade name: Vecoxan) belongs to a kind of coccidiostat and potent antiprotozoal agents. It is mainly used for the treatment, control, prevention and improvements of Coccidal infections. It alleviates the symptoms of the patients by interrupting the life cycle of the parasites. It induces the morphological changes and attenuates the mitochondrial transmembrane potential in meroites. It can prevent congenital toxoplasmosis and have anticoccidial effects in vivo. It is active through oral administration.

References

http://www.tabletwise.com/medicine/diclazuril https://en.wikipedia.org/wiki/Diclazuril http://www.abcam.com/diclazuril-ab143604.html

Chemical Properties

Light yellow or off-white powder, almost insoluble in water, slightly soluble in ethanol, ether, soluble in N,N-2 methylformamide (DMF), dimethylsulfone (DMSO), tetrahydrofuran (THF).

Uses

Diclazuril is a triazinone antiprotozoal that Nucleotide analog with broad-spectrum anticoccidial activity. It has a control effect on a variety of coccidiosis, and is used to prevent coccidiosis in chickens, ducks, quails, turkeys, geese and rabbits.

Veterinary Drugs and Treatments

Diclazuril is a coccidiostat. It is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona and as a coccidiostat in broiler chickens. Diclazuril could potentially be useful in treating coccidiosis, Neospora caninum and Toxoplasma infections in dogs or cats.

Check Digit Verification of cas no

The CAS Registry Mumber 101831-37-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,8,3 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 101831-37:
(8*1)+(7*0)+(6*1)+(5*8)+(4*3)+(3*1)+(2*3)+(1*7)=82
82 % 10 = 2
So 101831-37-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26)

101831-37-2 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0000259)  Diclazurilforsystemsuitability  European Pharmacopoeia (EP) Reference Standard

  • 101831-37-2

  • Y0000259

  • 1,880.19CNY

  • Detail
  • USP

  • (1188560)  Diclazuril  United States Pharmacopeia (USP) Reference Standard

  • 101831-37-2

  • 1188560-200MG

  • 4,326.66CNY

  • Detail

101831-37-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name Diclazuril

1.2 Other means of identification

Product number -
Other names DICLAZUTIL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:101831-37-2 SDS

101831-37-2Relevant articles and documents

Preparation method of triazinone ring

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, (2021/08/14)

A preparation method of a triazinone ring relates to the technical field of veterinary drugs, and comprises the following steps: carrying out a diazo condensation reaction on a condensation compound aniline and potassium ethyl malonate, carrying out an amidation reaction with sodium cyanate under an acidic condition, adding acetic acid and sodium acetate, heating, heating, and carrying out a cyclization reaction to obtain a triazinone compound. According to the method, operations such as filtration and separation are not needed before the finished product is obtained, the product loss is reduced, the method has the advantages of simple process and high yield, the yield of the salmizuril can reach 89.65%-94.81%, and the yield of the diclazuril can reach 80.20%-94.11%; and the problem of odor generation of decarboxylation reaction in the production process is also solved, and the method is beneficial to environmental protection and suitable for industrial production.

A coccidian preparation method

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, (2018/09/02)

The invention relates to a preparation method for diclazuril. A document reports that the synthesis of diclazuril is carried out in a such way that 2,6-dichloro-para-nitroaniline or 3,4,5-trichloronitrobenzene is used as an initial raw material and is subjected to diazotization reaction, substitution reaction, reduction reaction and the like to prepare a common intermediate 3. The existing process has many steps and is low in overall yield so that the costs of diclazuril raw materials and preparation stay at a high level. The invention provides a synthetic process of diclazuril. Particularly, the synthetic process comprises the steps that an intermediate 4 is prepared by performing reaction on the intermediate 3 and sodium nitrite by means of reduction and is subjected to cyclization and ring enlargement to obtain a product. In the route, a column chromatography means is not adopted; therefore, the process is short in the reaction steps and is suitable for industrial production.

1, 2, 4-Triazin-3-one derivatives, production and use thereof

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, (2008/06/13)

The present invention provides a novel triazine derivative of the formula STR1 wherein ring A is an optionally substituted aromatic group; X is an oxygen or sulfur atom; R1 and R6 are each a hydrogen atom or an optionally substituted hydrocarbon residue or heterocyclic group which may bound through a hetero-atom; R2 and R3 are each independently a hydrogen atom, a halogen atom, or a group bound through a carbon, oxygen or sulfur atom, or taken together, represent =S; R4 and R5 are each independently a hydrogen atom, a halogen-atom, or a group bound through a carbon, oxygen, nitrogen or sulfur atom; R1 and R2, and R5 and R6 may each bind together to form a chemical bond; provided that where ring A is a phenyl group having at least a halogen atom in position -2 or 4 and X is an oxygen atom, R4 and R5 do not conjoin to form a chemical bond, or a salt thereof. The invention also encompasses an antiprotozoan composition comprising the novel triazine derivative or a salt thereof.

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