101908-84-3

Basic information

• Product Name: Benzoic acid, 3-formyl-4,6-dimethoxy-2,5-dimethyl-, methyl ester
• CAS NO: 101908-84-3
• Molecular Formula: C13H16O5
• Molecular Weight: 252.267
• Mol File: 101908-84-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-formyl-4,6-dimethoxy-2,5-dimethyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-formyl-4,6-dimethoxy-2,5-dimethyl-, methyl ester(101908-84-3)
• EPA Substance Registry System: Benzoic acid, 3-formyl-4,6-dimethoxy-2,5-dimethyl-, methyl ester(101908-84-3)

Safety Data

• Hazardous Substances Data: 101908-84-3(Hazardous Substances Data)

Upstream product

• 4885-02-3 Dichloromethyl methyl ether 
• 58061-99-7 methyl 2,4-dimethoxy-3,6-dimethylbenzoate 
• 34874-90-3 methyl haematommate 
• 3187-58-4 methyl orsellinate 
• 4707-47-5 2,4-dihydroxy-3,6-dimethyl-benzoic acid methyl ester 
• 34874-76-5 formyl-3-dihydroxy-4,6-dimethyl-2,5-benzoate de methyle 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 

Downstream Products

• 148014-88-4 C₇₁H₇₂O₁₄ 
• 1027968-84-8 3-(3-Chlorocarbonyl-4,6-dimethoxy-2,5-dimethyl-benzyl)-4,6-dimethoxy-2,5-dimethyl-benzoic acid benzhydryl ester 
• 148014-56-6 C₂₅H₃₂O₈ 
• 148014-10-2 bis(3-carboxy-4,6-dimethoxy-2,5-dimethylphenyl)-Methane 
• 148014-55-5 (3-carbomethoxy-4,6-dihydroxy-2,5-dimethylphenyl)-(3-carbomethoxy-4,6-dimethoxy-2,5-dimethylphenyl)methane 
• 148014-54-4 3-Acetoxymethyl-4,6-dimethoxy-2,5-dimethyl-benzoic acid methyl ester 
• 245368-62-1 2,4-dimethoxy-3,6-dimethyl-5-(3-oxo-butyl)-benzoic acid methyl ester 
• 245368-63-2 2,4-dimethoxy-3,6-dimethyl-5-(3-oxo-butyl)-benzoic acid 
• 245368-64-3 2,4-dimethoxy-3,6-dimethyl-5-(3-oxo-butyl)-thiobenzoic acid S-methyl ester 
• 245368-65-4 resorthiomycin dimethyl ether 
• 148014-53-3 3-Hydroxymethyl-4,6-dimethoxy-2,5-dimethyl-benzoic acid methyl ester 

Relevant articles and documents

Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer

The synthesis and biological evaluation of thielocin B1 analogues have been demonstrated. Fourteen analogues modified in the central core and terminal carboxylic acid moiety were concisely synthesized by simple esterification or etherification reaction. The evaluation of synthetic analogues as inhibitors of proteasome assembling chaperone (PAC) complexes (the PAC3 homodimer and PAC1/PAC2) revealed that the natural product-like bending structure and terminal carboxylic acid groups were crucial for its biological activity. Moreover, SAR and in silico docking studies indicated that all methyl groups on the diphenyl ether moiety of thielocin B1 contribute to the potent and selective inhibition of the PAC3 homodimer via hydrophobic interactions.

First total synthesis of the antitumor antibiotic (±)-resorthiomycin

The first total synthesis of (±)-resorthiomycin, an antitumor antibiotic has been achieved.

205. Synthese d'une nouvelle depsidone derivee de l'acide furfurique, le dimethoxy-3,8-(dimethoxy-2,4-methoxycarbonyl-5-dimethyl-3,6-benzyl)-9-trimethyl-1,4,6-oxo-11-11H-dibenzodioxepinnecarboxylate-7 de methyle

The total synthesis of the title compound 1b is described.Starting from simple orcinol and β-orcinol units, the benzophenone 4 has been prepared.Using a biomimetic reaction, the intramolecular oxydative coupling, lead to the grisadienedione 25.By thermal interconversion and permethylation, the depsidone 1b has been obtained.