101935-40-4

Basic information

• Product Name: 2-Bromo-3-nitrophenol
• Synonyms: 2-BROMO-3-NITROPHENOL;2-BroMo-3-nitropheno;Phenol, 2-broMo-3-nitro-;101935-40-4
• CAS NO: 101935-40-4
• Molecular Formula: C₆H₄BrNO₃
• Molecular Weight: 218.00486
• Product Categories: Bromine Compounds;Nitro Compounds;Phenols
• Mol File: 101935-40-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 147.5°C
• Boiling Point: 248°C
• Flash Point: 104°C
• Appearance: /
• Density: 1.881
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.6090 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.39±0.25(Predicted)
• CAS DataBase Reference: 2-Bromo-3-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-nitrophenol(101935-40-4)
• EPA Substance Registry System: 2-Bromo-3-nitrophenol(101935-40-4)

Safety Data

• Hazardous Substances Data: 101935-40-4(Hazardous Substances Data)

Usage

General Description

2-Bromo-3-nitrophenol is a chemical compound with the molecular formula C6H4BrNO3. It is a yellow crystalline solid that is mainly used as an intermediate in the synthesis of pharmaceuticals, dyes, and agrochemicals. It is also used as a starting material in the production of other organic compounds and is a versatile building block in organic chemistry. 2-Bromo-3-nitrophenol is mainly produced through the nitration of 2-bromophenol, and it is important to handle it with care as it is toxic and harmful if ingested or inhaled. 2-Bromo-3-nitrophenol has also shown potential biological activity and is being studied for its antimicrobial and antitumor properties.

InChI:InChI=1/C6H4BrNO3/c7-6-4(8(10)11)2-1-3-5(6)9/h1-3,9H

Upstream product

• 603-85-0 2-Amino-3-nitrophenol 
• 554-84-7 meta-nitrophenol 
• 7726-95-6 bromine 
• 67853-37-6 2-bromo-1-methoxy-3-nitrobenzene 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 112970-61-3 2-bromo-3-nitrophenyl trifluoromethanesulfonate 
• 13073-25-1 2-bromo-6-nitro-phenol 
• 5344-78-5 4-bromo-3-nitroanizole 

Downstream Products

• 153136-82-4 ethyl (2E)-3-(2-hydroxy-6-nitrophenyl)prop-2-enoate 
• 205187-37-7 2-bromo-3-isopropoxy-nitrobenzene 
• 1202677-59-5 4'-benzyloxy-6-nitro-biphenyl-2-ol 
• 863870-88-6 2-bromo-3-iodophenol 

Relevant articles and documents

Chemoselectivity in the Kosugi-Migita-Stille coupling of bromophenyl triflates and bromo-nitrophenyl triflates with (ethenyl)tributyltin

Kosugi-Migita-Stille cross coupling reactions of (ethenyl)tributyltin with all isomeric permutations of bromophenyl triflate and bromo-nitrophenyl triflate were examined in order to determine the chemoselectivity of carbon-bromine versus carbon-triflate bond coupling under different reaction conditions. In general, highly selective carbon-bromine bond cross couplings were observed using for example bis(triphenylphosphine)palladium dichloride (2 mol-%) in 1,4-dioxane at reflux. In contrast, reactions using the same pre-catalyst but in the presence of a three-fold excess of lithium chloride in N,N-dimethylformamide at ambient temperature were in most cases selective for coupling at the carbon-triflate bond. Overall, isolated yields and the selectivity for carbon-bromine bond coupling were significantly higher compared to carbon-triflate bond coupling.

CHEMICAL COMPOUNDS

A compound of the formula (I) where, for example, W, X and Y are each CH; R1 and R6, independently of each other, are for example, selected from the group consisting of H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C3-C

DI-SUBSTITUTED PHENYL COMPOUNDS

Di-substituted phenyl compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) f