1019854-25-1Relevant articles and documents
Enantioselective total synthesis of (+)-rubrobramide, (+)-talaramide A, and (?)-berkeleyamide D by a skeletal diversification strategy
Tanaka, Kosaku,Kobayashi, Kenichi,Kogen, Hiroshi
, p. 9780 - 9783 (2021/09/30)
A unified synthesis of (+)-rubrobramide, (+)-talaramide A, and (?)-berkeleyamide D was achieved from the vinylogous esters by a skeletal diversification strategy based on regioselective 5-exoor 6-endocyclization. This report describes the first enantioselective total synthesis of (+)-rubrobramide and (+)-talaramide A. Additionally, synthetic spirocyclic lactam compounds, including (?)-berkeleyamide D, showed moderate inhibitory activity against amyloid-β aggregation for the potential treatment of Alzheimer's disease.
