102-48-7

Basic information

• Product Name: (3,4-Dimethylphenyl)methanamine
• Synonyms: 3,4-DIMETHYLBENZYLAMINE;RARECHEM AL BW 0353;(3,4-Dimethylphenyl)methanamine;3,4-dimethyl-benzenemethanamin;Benzylamine, 3,4-dimethyl-;3,4-DIMETHYLBENZYLAMINE HCL;3,4-dimethylbenzylamine hydrochloride;3,4-dimethyl-Benzenemethanamine
• CAS NO: 102-48-7
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 135.21
• EINECS: 203-034-6
• Product Categories: Amines and Anilines;Anilines, Aromatic Amines and Nitro Compounds;Amine;Benzenes
• Mol File: 102-48-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 93 °C
• Flash Point: 93.9 °C
• Appearance: /
• Density: 0.95
• Vapor Pressure: 0.0811mmHg at 25°C
• Refractive Index: 1.5350 to 1.5390
• Storage Temp.: 2-8°C
• PKA: 9.28±0.10(Predicted)
• CAS DataBase Reference: (3,4-Dimethylphenyl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-Dimethylphenyl)methanamine(102-48-7)
• EPA Substance Registry System: (3,4-Dimethylphenyl)methanamine(102-48-7)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 102-48-7(Hazardous Substances Data)

Usage

General Description

(3,4-Dimethylphenyl)methanamine, also known as 3,4-Dimethylbenzylamine, serves as a valuable intermediate in organic synthesis and pharmaceutical research. Its versatile chemical structure allows it to participate in various chemical reactions, making it a key building block for the creation of more complex molecules.

InChI:InChI=1/C9H13N/c1-7-3-4-9(6-10)5-8(7)2/h3-5H,6,10H2,1-2H3

Upstream product

• 22884-95-3 3,4-dimethylbenzonitrile 
• 100-46-9 benzylamine 

Downstream Products

• 51623-15-5 1-(3,4-dimethyl-benzyl)-3-thiazol-2-yl-thiourea 
• 96275-57-9 N,N',N''-Tris-<3,4-dimethyl-benzyl>-guanidin 
• 936219-12-4 3-(2,3-dichlorophenyl)-4-(3,4-dimethylbenzyl)-4H-1,2,4-triazole 
• 865713-88-8 4-chloro-N-[(3,4-dimethylphenyl)methyl]-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 
• 247568-43-0 2-[1-(tert-butoxycarbonyl)-4-piperidinylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-98-9 2-(1-Benzylpiperidin-4-ylamino)-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-97-8 2-[1-(Ethoxycarbonyl)piperidin-4-ylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247568-42-9 2-(4-carboxycyclohexylamino)-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247568-41-8 2-[4-(methoxycarbonyl)cyclohexylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247567-04-0 2-[1-(Hydroxymethyl)cyclopentylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247566-99-0 2-[2-Hydroxy-1,1-bis(hydroxymethyl)ethylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 

Relevant articles and documents

Versatile Dynamic Covalent Assemblies for Probing π-Stacking and Chirality Induction from Homotopic Faces

Herein we report for the first time the use of dynamic covalent reactions (DCRs) for building a π-stacking model system and further quantifying its substituent effects (SEs), which remain a topic of debate despite the rich history of stacking. A general DCR between 10-methylacridinium ion and primary amines was discovered, in which π-stacking played a stabilizing role. Facile quantification of SEs with in situ competing π-stacking systems was next achieved in the form of amine exchange exhibiting structural diversity by simply varying components. The linear correlation with σm in Hammett plots indicates the dominance of purely electrostatic SEs, and the additivity of SEs is in line with the direct interaction model. With α-chiral amines π-stacking within the adduct enabled chirality transfer from homotopic faces. The strategy of dynamic covalent assembly should be appealing to future research of probing weak interactions and manipulating chirality.

Relationships between structure and action of primary amines and amino acids in the inhibition of trypsin

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