1020069-04-8

Basic information

• Product Name: 4-benzyl-5-isopropyl-2,6-bis-trimethylsilanyloxy-pyrimidine
• Synonyms: 4-benzyl-5-isopropyl-2,6-bis-trimethylsilanyloxy-pyrimidine
• CAS NO: 1020069-04-8
• Molecular Weight: 388.657
• Mol File: 1020069-04-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-benzyl-5-isopropyl-2,6-bis-trimethylsilanyloxy-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-5-isopropyl-2,6-bis-trimethylsilanyloxy-pyrimidine(1020069-04-8)
• EPA Substance Registry System: 4-benzyl-5-isopropyl-2,6-bis-trimethylsilanyloxy-pyrimidine(1020069-04-8)

Safety Data

• Hazardous Substances Data: 1020069-04-8(Hazardous Substances Data)

Upstream product

• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 176519-55-4 6-benzyl-5-isopropylpyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 1020069-06-0 C₃₂H₃₅N₃O₈ 
• 149950-60-7 Emivirine 
• 1237521-88-8 1-((3-(4-acetylphenyl)propoxy)methyl)-6-benzyl-5-isopropylpyrimidine-2,4(1H,3H)-dione 
• 1237521-81-1 1-((4-(3-acetylbenzyl)benzyloxy)methyl)-6-benzyl-5-isopropylpyrimidine-2,4(1H,3H)-dione 
• 1237521-87-7 1-((4-acetylphenethoxy)methyl)-6-benzyl-5-isopropyl-pyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

Pharmacophore and structure-activity relationships of integrase inhibition within a dual inhibitor scaffold of HIV reverse transcriptase and integrase

Rational design of dually active inhibitors against human immunodeficiency virus (HIV) reverse transcriptase (RT) and integrase (IN) has proved viable with 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) type of non-nucleoside RT inhibitors (NNRTIs). To establish the pharmacophore and study the structure-activity relationships (SAR) of integrase inhibition within a previously disclosed RT/IN dual inhibitor scaffold, new analogues featuring substitution at different sites of the HEPT ring were designed and synthesized. These studies have revealed an IN inhibition pharmacophore that is merged with the known RT pharmacophore through a shared C-6 benzyl group. Further SAR also demonstrated that optimal IN inhibition within our dual inhibitor scaffold requires a regiospecific (N-1) diketoacid (DKA)-carrying pendant with a certain length.