1020396-02-4

Basic information

• Product Name: KI-063
• CAS NO: 1020396-02-4
• Molecular Weight: 330.381
• Mol File: 1020396-02-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: KI-063(CAS DataBase Reference)
• NIST Chemistry Reference: KI-063(1020396-02-4)
• EPA Substance Registry System: KI-063(1020396-02-4)

Safety Data

• Hazardous Substances Data: 1020396-02-4(Hazardous Substances Data)

Upstream product

• 18979-61-8 4-butylresorcinol 
• 1078-61-1 dihydrocaffeic acid 

Relevant articles and documents

The hypopigmentary action of KI-063 (a new tyrosinase inhibitor) combined with terrein

Resorcinol derivatives are known to inhibit melanin synthesis. In this study, resorcinol derivatives were synthesized and screened for their activity on melanogenesis. KI-063 (a tyrosinase inhibitor) was examined for its effects on melanogenesis using a spontaneously immortalized mouse melanocyte cell line (Mel-Ab). In a cell-free system, KI-063 directly inhibited tyrosinase, the rate-limiting melanogenic enzyme. Moreover, in a cell system, it inhibited melanin synthesis in a concentration-dependent manner. In addition, KI-063 inhibited the activity of cellular tyrosinase. Thus, this study examined the effects of a combination of KI-063 with terrein, an agent that down-regulates microphthalmia-associated transcription factor. The data suggest that KI-063 has an additive effect in combination with terrein. Thus, the suppression of tyrosinase activity by KI-063 and the inhibition of tyrosinase production by terrein appear to be an optimal combination for skin whitening.