102072-82-2

Basic information

• Product Name: 6,7-dichloroquinoxaline-5,8-dione
• Synonyms: 5,8-Quinoxalinedione, 6,7-dichloro-; 6,7-Dichloro-5,8-quinoxalinedione
• CAS NO: 102072-82-2
• Molecular Formula: C₈H₂Cl₂N₂O₂
• Molecular Weight: 229.0197
• Mol File: 102072-82-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 341.5°C at 760 mmHg
• Flash Point: 160.4°C
• Density: 1.72g/cm³
• Vapor Pressure: 7.99E-05mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: 6,7-dichloroquinoxaline-5,8-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dichloroquinoxaline-5,8-dione(102072-82-2)
• EPA Substance Registry System: 6,7-dichloroquinoxaline-5,8-dione(102072-82-2)

Safety Data

• Hazardous Substances Data: 102072-82-2(Hazardous Substances Data)

Upstream product

• 19506-19-5 5,8-dimethoxyquinoxaline 
• 150-78-7 1,4-dimethoxybezene 
• 15250-38-1 quinoxaline-5,8-dione 

Downstream Products

• 218271-03-5 N-[7-(4-Bromo-phenylamino)-5,8-dioxo-5,8-dihydro-quinoxalin-6-yl]-acetamide 
• 218271-09-1 1-(4-Bromo-phenyl)-2-methyl-1H-imidazo[4,5-g]quinoxaline-4,9-dione 

Relevant articles and documents

Design, synthesis, and cytotoxicity of indolizinoquinoxaline-5,12-dione derivatives, novel DNA topoisomerase IB inhibitors

A series of new indolizinoquinoxaline-5,12-dione derivatives were designed and synthesized via a heterocyclization reaction of 6,7-dichloroquinoxaline-5,8- dione with active methylene reagents and pyridine derivatives. The synthesized compounds exhibited significant activity to inhibit the growth of four human tumour cell lines, including lung adenocarcinoma cell, large-cell lung carcinoma cell, breast carcinoma cell, and ardriamycin-resistant breast carcinoma cell at micromolar range. These compounds were also investigated for their inhibition to DNA topoisomerase IB activity. The results indicated that the indolizinoquinoxaline-5,12-dione structure might be a potential pharmacophore in anti-cancer drug design.

Streptonigrin. 1. Structure-activity relationships among simple bicyclic analogues. Rate dependence of DNA degradation on quinone reduction potential

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