1021355-00-9Relevant articles and documents
Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition
Hargreaves, Robert H. J.,David, Cynthia L.,Whitesell, Luke J.,LaBarbera, Daniel V.,Jamil, Akmal,Chapuis, Jean C.,Skibo, Edward B.
, p. 2492 - 2501 (2008/12/21)
A series of substituted quinoline-5,8-diones were synthesized and evaluated as inhibitors of the chaperone protein Hsp90 using two assays: competition for binding to C-terminal ATP-binding site and competition for binding to N-terminal ATP-binding site. I
