102162-75-4

Basic information

• Product Name: 3,3-bis-(4-methoxy-phenyl)-propionic acid ethyl ester
• CAS NO: 102162-75-4
• Molecular Weight: 314.381
• Mol File: 102162-75-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,3-bis-(4-methoxy-phenyl)-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-bis-(4-methoxy-phenyl)-propionic acid ethyl ester(102162-75-4)
• EPA Substance Registry System: 3,3-bis-(4-methoxy-phenyl)-propionic acid ethyl ester(102162-75-4)

Safety Data

• Hazardous Substances Data: 102162-75-4(Hazardous Substances Data)

Upstream product

• 102162-83-4 3-hydroxy-3,3-bis-(4-methoxy-phenyl)-propionic acid ethyl ester 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 31892-99-6 ethyl 3,3-bis(4'-methoxyphenyl)prop-2-enoate 
• 100-09-4 4-methoxybenzoic acid 
• 100-66-3 methoxybenzene 

Downstream Products

• 35582-69-5 bis-3,3-(p-methoxyphenyl)-propionic acid 
• 111161-77-4 5,5-bis-(4-methoxy-phenyl)-valeric acid 
• 110154-72-8 3,3-bis-(4-methoxy-phenyl)-propan-1-ol 

Relevant articles and documents

New orally active diphenylmethyl-based ester analogues of dihydroartemisinin: Synthesis and antimalarial assessment against multidrug-resistant Plasmodium yoelii nigeriensis in mice

A new series of ester analogues of artemisinin 8a–f, incorporating diphenylmethyl as pharmacologically privileged substructure, and 8g–j have been prepared and evaluated for their antimalarial activity against multidrug-resistant (MDR) Plasmodium yoelii nigeriensis in Swiss mice via oral route. These diphenylmethyl-based ester analogues 8a–f were found to be 2–4 folds more active than the antimalarial drugs β-arteether 4 and artesunic acid 5. Ester 8a, the most active compound of the series, provided complete protection to the infected mice at 24?mg/kg?×?4?days as well as 12?mg/kg?×?4?days, respectively. In this model β-arteether provided 100% and 20% protection at 48?mg/kg?×?4?days and 24?mg/kg?×?4?days, respectively.