1021867-92-4

Basic information

• Product Name: 3-(3-cyclopentyloxy-4-methoxy-phenyl)-4-nitro-butyric acid methyl ester
• Synonyms: 3-(3-cyclopentyloxy-4-methoxy-phenyl)-4-nitro-butyric acid methyl ester
• CAS NO: 1021867-92-4
• Molecular Weight: 337.373
• Mol File: 1021867-92-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3-(3-cyclopentyloxy-4-methoxy-phenyl)-4-nitro-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-cyclopentyloxy-4-methoxy-phenyl)-4-nitro-butyric acid methyl ester(1021867-92-4)
• EPA Substance Registry System: 3-(3-cyclopentyloxy-4-methoxy-phenyl)-4-nitro-butyric acid methyl ester(1021867-92-4)

Safety Data

• Hazardous Substances Data: 1021867-92-4(Hazardous Substances Data)

Upstream product

• 154464-26-3 3-(cyclopentyloxy)-4-methoxybenzenamine 
• 53606-42-1 N-(3-Acetoxy-4-methoxyphenyl)acetamide 
• 75-52-5 nitromethane 
• 133332-20-4 (E)-methyl-3-<3-(cyclopenyloxy)-4-methoxyphenyl>prop-2-enoate 
• 51-66-1 4-methoxyacetanilide 
• 3251-57-8 N-(3-hydroxy-4-methoxyphenyl)acetamide 
• 1197924-28-9 3-cyclopentyloxy-4-methoxyacetanilide 
• 67-56-1 methanol 
• 133332-34-0 (E)-3-(3-cyclopentyloxy-4-methoxyphenyl)acrylaldehyde 
• 67387-76-2 3-cyclopentyloxy-4-methoxybenzylaldehyde 
• 621-59-0 isovanillin 
• 1402406-56-7 (R)-3-(3-(cyclopentyloxy)-4-methoxyphenyl)-4-nitrobutan-1-ol 
• 1402406-47-6 (R)-2-(cyclopentyloxy)-1-methoxy-4-(1-nitrobut-3-en-2-yl)benzene 
• 209112-33-4 C₁₆H₂₁NO₆ 

Downstream Products

• 61413-54-5 Rolipram 
• 1443535-38-3 N-methyl rolipram 
• 1443535-39-4 C₁₉H₂₉NO₄ 
• 85416-75-7 (R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one 

Relevant articles and documents

Efficient synthesis of (?)-(R)- and (+)-(S)-rolipram

A novel, efficient and protecting group free enantioselective synthetic approach of (?)-(R)-1 and (+)-(S)-rolipram 2 is described employing the organocatalyzed asymmetric Michael addition, Henry condensation, Wittig olefination and reductive lactamization

From paracetamol to rolipram and derivatives: Application of deacetylation-diazotation sequences and palladium-catalyzed matsuda-heck reaction

A six-step synthesis of the antidepressant rolipram from the popular analgetic 4-acetamidophenol (paracetamol) is described. The steps include oxidative functionalization of the aromatic core, diazonium salt formation via deacetylation-diazotation, Matsuda-Heck reaction, conjugate addition of nitromethane, and hydrogenative cyclization. Georg Thieme Verlag Stuttgart · New York.

Regio- and enantioselective palladium-catalyzed allylic alkylation of nitromethane with monosubstituted allyl substrates: Synthesis of (R)-rolipram and (R)-baclofen

The Pd-catalyzed asymmetric allylic alkylation (AAA) reaction of nitromethane with monosubstituted allyl substrates was realized for the first time to provide corresponding products in high yields with excellent regio- and enantioselectivities. The protocol was applied to the enantioselective synthesis of (R)-baclofen and (R)-rolipram.