1021919-30-1Relevant articles and documents
Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3Kδ inhibitor: Design, synthesis and biological evaluation
Yang, Chengbin,Xu, Chenyue,Li, Zhipeng,Chen, Yi,Wu, Tianze,Hong, Hui,Lu, Mingzhu,Jia, Yu,Yang, Yongtai,Liu, Xiaofeng,Deng, Mingli,Chen, Zhenxia,Li, Qingquan,Ling, Yun,Zhou, Yaming
supporting information, (2021/07/10)
Based on indole scaffold, a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor, namely FD223, was developed by the bioisosteric replacement drug discovery approach and studied for the treatment of acute myeloid leukemia (AML). In vitro
HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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Page/Page column 190-191, (2008/12/05)
Provided herein are Heteroaryl Compounds having the following structure: (I) wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.