102203-18-9 Usage
Description
IMETIT DIHYDROBROMIDE, also known as an imidothiocarbamic ester, is a potent agonist at histamine H3 and H4 receptors. It consists of isothiourea with a 2-(imidazol-4-yl)ethyl group substitution on the thiol hydrogen. IMETIT DIHYDROBROMIDE exhibits extremely high affinity for both H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. IMETIT DIHYDROBROMIDE is capable of inducing shape change in eosinophils with an EC50 of 25 nM and remains centrally active following systemic administration.
Uses
Used in Pharmaceutical Industry:
IMETIT DIHYDROBROMIDE is used as a research compound for studying the histamine H3 and H4 receptors. Its high affinity for these receptors makes it a valuable tool in understanding the role of histamine in various physiological processes and potential therapeutic applications.
Used in Central Nervous System Applications:
IMETIT DIHYDROBROMIDE is used as a central nervous system agent due to its ability to induce shape change in eosinophils and its central activity following systemic administration. This property makes it a potential candidate for the development of treatments targeting conditions related to the central nervous system.
Used in Histamine Receptor Research:
IMETIT DIHYDROBROMIDE is used as a histamine receptor agonist in the field of histamine receptor research. Its potent and selective action on H3 and H4 receptors allows for the investigation of the roles these receptors play in various physiological and pathological processes, potentially leading to the development of new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 102203-18-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,2,0 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 102203-18:
(8*1)+(7*0)+(6*2)+(5*2)+(4*0)+(3*3)+(2*1)+(1*8)=49
49 % 10 = 9
So 102203-18-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10)
