102245-02-3

Basic information

• Product Name: (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE
• Synonyms: (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE
• CAS NO: 102245-02-3
• Molecular Formula: C₁₂H₁₂ClNO₃
• Molecular Weight: 253.68158
• Mol File: 102245-02-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE(102245-02-3)
• EPA Substance Registry System: (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE(102245-02-3)

Safety Data

• Hazardous Substances Data: 102245-02-3(Hazardous Substances Data)

Usage

General Description

(Z)-Methyl 2-acetamido-3-(4-chlorophenyl)acrylate is an organic compound that belongs to the class of esters. It is a white solid with a molecular formula of C13H12ClNO3 and a molecular weight of 259.69 g/mol. (Z)-METHYL 2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLATE is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has also been reported as a potential building block for the preparation of various biologically active compounds. The (Z)-Methyl 2-acetamido-3-(4-chlorophenyl)acrylate can undergo reactions such as hydrolysis, reduction, and addition to form new compounds with different properties and applications. Overall, this chemical has great potential for use in various industries due to its versatility and ability to be modified into different forms for different purposes.

Upstream product

• 93634-55-0 2-methyl-4-(4-chlorobenzylidene)-4H-oxazol-5-one 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 
• 104-88-1 4-chlorobenzaldehyde 
• 543-24-8 N-acetylglycine 
• 93634-55-0 (Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 88681-63-4 (Z)-2-acetamido-3-(4-chlorophenyl)acrylic acid 
• 106-39-8 bromochlorobenzene 
• 35356-70-8 Methyl 2-acetamidoacrylate 
• 108-24-7 acetic anhydride 
• 102244-86-0 (Z)-methyl 2-azido-3-(4-chlorophenyl)acrylate 

Downstream Products

• 105962-35-4 methyl Z-2-acetamido-3-p-chlorophenyl-2-butanoate 
• 111016-44-5 4-(4-chloro-phenyl)-1⁽²⁾H-pyrazole-3-carboxylic acid methyl ester 
• 111016-49-0 4-(4-chlorophenyl)-1H-pyrazole-3-carboxylic acid 
• 111016-47-8 4-(4-chlorophenyl)-1H-pyrazole 
• 312300-60-0 methyl (E)-2-acetylamino-3-(4-chlorophenyl)-2-propenoate 
• 93634-74-3 methyl (S)-2-acetamido-3-(4-chlorophenyl)propanoate 
• 93634-74-3 N-acetyl-(R)-3-(4-chlorophenyl)alanine methyl ester 
• 129496-71-5 methyl 2-acetylamino-3-(4-chlorophenyl)propanoate 
• 105962-47-8 cis-4-p-chlorophenyl-3-acetamido-3-carbomethoxy-Δ¹-pyrazoline 

Relevant articles and documents

Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands

The development of chiral architectures for chiral ligand and catalyst discovery is essential for asymmetric catalysis. Herein, we report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chemical resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asymmetric reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asymmetric catalysis. This journal is

Ni(ii)-Catalyzed vinylic C-H functionalization of 2-acetamido-3-arylacrylates to access isotetronic acids

A ligand-free Ni(ii)-catalyzed cascade annulation reaction for the synthesis of 4-aryl-substituted isotetronic acids from 2-acetamido-3-arylacrylatesviavinylic C-H functionalization is reported. The reaction proceeds through heteroatom guided electrophilic insertion of nickel to the vinylic double bond followed by annulation with dibromomethane. This unconventional route features cascade steps, sole product formation, multiple functional group tolerance, low cost of catalysts and reagents, and readily available starting materials. Using this method, various aryl-substituted isotetronic acids have been synthesized which are biologically relevant. The annulation of 2-acetamido-3-arylacrylates has also been assessed with 1,2-dichloroethane, which resulted in the rearranged annulated products of 5-methyl substituted isotetronic acids.

Temperature-controlled bidirectional enantioselectivity in a dynamic catalyst for asymmetric hydrogenation

Asymmetric catalysis using enantiomerically pure catalysts is one of the most widely used methods for the preparation of enantiomerically pure compounds. The separate synthesis of both enantiomerically pure compounds requires tedious and time-consuming pr