102312-67-4Relevant articles and documents
Synthesis and structures of fused N-heterocylic carbenes and their rhodium complexes
Li, Jean,Stewart, Ian C.,Grubbs, Robert H.
scheme or table, p. 3765 - 3768 (2010/12/20)
New procedures for the synthesis of N-heterocyclic carbenes with multiple fused rings have been developed utilizing a key ring-closing metathesis step. Rhodium complexes were obtained via the pentafluorophenyl carbene adducts. Solid-state structural behav
Hydrolysis of cyclic ureas under microwave irradiation: Synthesis and characterization of 7,8-diaminopelargonic acid
Vasanthakumar, Ganga Ramu,Bhor, Vikrant M.,Surolia, Avadhesha
, p. 2633 - 2639 (2008/02/12)
A simple and efficient method for the synthesis of 7,8-diaminopelargonic acid, a key intermediate in the biotin biosynthesis pathway, is reported. The d-desthiobiotin powder was dissolved in concentrated hydrochloric acid, and the solution was exposed to microwave radiation of 2.45 GHz for varying lengths of time ranging from 60 s to 2 min. The product thus obtained was characterized by spectroscopic techniques and confirmed through bioassay. Further, the protocol was extended to the synthesis of several diamines from their corresponding cyclic ureas. The results show that the method is generally applicable and not only accelerates the hydrolysis reaction but also offers excellent yields. Copyright Taylor & Francis Group, LLC.
Hepatobiliary magnetic resonance contrast agents
-
Page 16, (2010/01/31)
A compound of the formula: wherein ???R1 and R2 are both hydrogen and R3 and R4 together with the carbon atoms in the tetraazacyclododecane macrocycle to which they are attached form a fused fully or partially saturated non aromatic cyclohexyl ring which may be unsubstituted or substituted by one or more halogen, straight or branched (C1-C5)alkyl, alkyl oxide of formula -R-OR wherein each R is a straight or branched (C1-C5)alkyl, hydroxy or hydroxyalkyl groups, and which may be further fused to a phenyl or cyclohexyl ring p is 0 or 1 and R6 is hydrogen or a straight or branched (C1-C5) alkyl group; or a salt thereof and the metal chelates thereof, particularly gadolinium chelates, the pharmaceutical and diagnostic compositions containing them and their use in MRI.