1023700-90-4

Basic information

• Product Name: (S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester
• Synonyms: (S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester
• CAS NO: 1023700-90-4
• Molecular Weight: 402.759
• Mol File: 1023700-90-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester(1023700-90-4)
• EPA Substance Registry System: (S)-2-(4-bromo-3-chloro-benzylamino)-4-methyl-pentanoic acid cyclopentyl ester(1023700-90-4)

Safety Data

• Hazardous Substances Data: 1023700-90-4(Hazardous Substances Data)

Upstream product

• 914382-66-4 (S)-cyclopentyl 2-amino-4-methylpentanoate 4-methylbenzenesulfonate 
• 120077-69-2 3-chloro4-bromo-benzaldehyde 

Downstream Products

• 1023700-89-1 cyclopentyl N-[3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-L-leucinate 

Relevant articles and documents

IKK-β SERINE-THREONINE PROTEIN KINASE INHIBITORS

Compounds of formula (IA) or (IB) are inhibitors of IkB kinase (IKK) activity, and are useful in the treatment of autoimmune and inflammatory diseases: Formula (A) and (B) wherein R7 is hydrogen or optionally substituted (C1-C6)alkyl; ring A is an optionally substituted aryl or heteroaryl ring of 5-13 ring atoms; Z is (a) a radical of formula R1R2CHNH-Y-L1-X1-(CH2)Z- wherein: z is 0 or 1; R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non- natural alpha amino acid; Y is a bond, -C(=O)-, -S(=O)2-, -C(=O)O-, -C(=O)NR3-, - C(=S)-NR3, -C(=NH)-NR3 or -S(=O)2NR3- wherein R3 is hydrogen or optionally substituted C1-C6 alkyl; L1 is a divalent linker radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, Q, AIk1 and AIk2 are as defined in the claims.