102396-62-3

Basic information

• Product Name: 5-<(4-nitrophenyl)hydroxymethyl>-2,4(1H,3H)-pyrimidinedione
• CAS NO: 102396-62-3
• Molecular Weight: 263.21
• Mol File: 102396-62-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-<(4-nitrophenyl)hydroxymethyl>-2,4(1H,3H)-pyrimidinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-<(4-nitrophenyl)hydroxymethyl>-2,4(1H,3H)-pyrimidinedione(102396-62-3)
• EPA Substance Registry System: 5-<(4-nitrophenyl)hydroxymethyl>-2,4(1H,3H)-pyrimidinedione(102396-62-3)

Safety Data

• Hazardous Substances Data: 102396-62-3(Hazardous Substances Data)

Upstream product

• 1000372-64-4 5-[chloro-(4-nitro-phenyl)-methyl]-1H-pyrimidine-2,4-dione 
• 555-16-8 4-nitrobenzaldehdye 
• 66-22-8 uracil 

Relevant articles and documents

Synthesis and cytotoxic activity of various 5-[alkoxy-(4-nitro-phenyl)-methyl]-uracils in their racemic form

The preparation of various 5-[alkoxy-(4-nitro-phenyl)-methyl]-uracils with alkyl chain lengths C1-C12 is described. The synthesis is based on the preparation of 5-[chloro-(4-nitro-phenyl)-methyl]-uracil and subsequent substitution of chlorine with appropriate alcohols. The resulting ethers were tested for their cytotoxic activity in vitro against five cancer cell lines. The compounds were less active in lung resistance protein expressing cell lines, suggesting the involvement of this multidrug resistant protein in control of the biological activity. Cytotoxic substances induced rapid inhibition of DNA and modulation of RNA synthesis followed by induction of apoptosis. The data indicate that the biological activity of 5-[alkoxy-(4-nitro-phenyl)-methyl]-uracils depends on the alkyl chain length.