10240-19-4

Basic information

• Product Name: isogalcatin
• CAS NO: 10240-19-4
• Molecular Weight: 340.419
• Mol File: 10240-19-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: isogalcatin(CAS DataBase Reference)
• NIST Chemistry Reference: isogalcatin(10240-19-4)
• EPA Substance Registry System: isogalcatin(10240-19-4)

Safety Data

• Hazardous Substances Data: 10240-19-4(Hazardous Substances Data)

Upstream product

• 77516-07-5 (1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-6,7-dimethoxy-3-methyl-4-oxo-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid dimethylamide 
• 77516-07-5 (1S,2R,3R)-1-Benzo[1,3]dioxol-5-yl-6,7-dimethoxy-3-methyl-4-oxo-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid dimethylamide 
• 77516-08-6 (1S,2S,3R)-1-Benzo[1,3]dioxol-5-yl-6,7-dimethoxy-3-methyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid dimethylamide 
• 77516-09-7 (5S,6S,7R)-5-Benzo[1,3]dioxol-5-yl-6-hydroxymethyl-3-methoxy-7-methyl-5,6,7,8-tetrahydro-naphthalen-2-ol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 78647-55-9 3-hydroxymethyl-6,7-dimethoxy-1-(3',4'-methylenedioxyphenyl)-1,2,3,4-tetrahydro-2-naphthoic acid γ-lactone 
• 78647-52-6 (+/-)-4-(3,4-dimethoxyphenyl)-3-methoxycarbonylbutanoic acid 
• 115061-18-2 (E)-3-(methoxycarbonyl)-4-(3,4-dimethoxyphe-nyl)but-3-enoic acid 
• 72430-92-3 4-[(3,4-dimethoxyphenyl)methyl]dihydrofuran-2-one 
• 120-57-0 piperonal 
• 10240-16-1 (6S,7R,8R)-8-Benzo[1,3]dioxol-5-yl-3-methoxy-6,7-dimethyl-5,6,7,8-tetrahydro-naphthalen-2-ol 
• 77-78-1 dimethyl sulfate 
• 78647-56-0 t-2,c-3-bishydroxymethyl-6,7-dimethoxy-r-1-(3,4-methylenedioxyphenyl)-1,2,3,4-tetrahydronaphthalene 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 

Relevant articles and documents

Design, synthesis and biological evaluation of substituted (+)-SG-1 derivatives as novel anti-HIV agents

SG-1 was previously identified as a potent Non-nucleoside reverse transcriptase inhibitors (NNRTI) which works through inhibition of reverse transcriptase (RT) RNA-dependent DNA polymerase activity via a direct binding event. To further investigate the relationship between its structure and activity, four series of novel analogues were designed and synthesized with 12 of them inhibiting HIV-1 replication with IC50s in the range 0.09–6.71 μM. Compound 4b, 4c, 4f, 2 and 6b were further tested on two NNRTI-resistant HIV-1 strains and one NNRTI-resistant superbug. The result showed that RT- E138K/M184V mutant virus conferred 4.7–9.1-fold resistance to 4c, 4f, 2 and 6b, but only showed slight resistance to 4b (2-fold) which was better than SG-1.

TANDEM CONJUGATE ADDITION-α-ALKYLATION OF UNSATURATED AMIDES. SYNTHESIS OF 1-ARYLTETRALIN LIGNANS

The amide alcohols 5,6, obtained in one step from the sequential reaction of N,N-dimethylcrotonamide with dithiane 3 anion and aryl aldehyde 4, were efficiently converted into the lignans galcatin (2a) and isogalcatin (2b).