1025027-36-4

Basic information

• Product Name: 1,1,1,2-tetrafluoro-2-(trifluoromethyl)-4-iodo-5-phenylpentane
• Synonyms: 1,1,1,2-tetrafluoro-2-(trifluoromethyl)-4-iodo-5-phenylpentane
• CAS NO: 1025027-36-4
• Molecular Weight: 414.105
• Mol File: 1025027-36-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,1,1,2-tetrafluoro-2-(trifluoromethyl)-4-iodo-5-phenylpentane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1,2-tetrafluoro-2-(trifluoromethyl)-4-iodo-5-phenylpentane(1025027-36-4)
• EPA Substance Registry System: 1,1,1,2-tetrafluoro-2-(trifluoromethyl)-4-iodo-5-phenylpentane(1025027-36-4)

Safety Data

• Hazardous Substances Data: 1025027-36-4(Hazardous Substances Data)

Upstream product

• 300-57-2 allylbenzene 
• 677-69-0 perfluoroisopropyl iodide 

Downstream Products

• 122129-09-3 (1E)-5,5,5-trifluoro-1-phenyl-4-(trifluoromethyl)-1,3-pentadiene 

Relevant articles and documents

Aqueous-Medium Carbon-Carbon Bond-Forming Radical Reactions Catalyzed by Excited Rhodamine B as a Metal-Free Organic Dye under Visible Light Irradiation

The utility of rhodamine B as a water-soluble organic photocatalyst was studied in the cascade radical addition-cyclization-trapping reactions under visible light irradiation. In the presence of (i-Pr)2NEt, the electron transfer from the excited rhodamine B to perfluoroalkyl iodides proceeded smoothly to promote the carbon-carbon bond-forming radical reactions in aqueous media. When i-C3F7I was employed as a radical precursor, the aqueous-medium radical reactions proceeded even in the absence of (i-Pr)2NEt. In these reactions, the direct electron transfer from the excited singlet state of rhodamine B would take place. Furthermore, the cleavage of the C-I bond in less reactive i-PrI could be achieved by the reductive electron transfer from the excited rhodamine B, which was confirmed by the fluorescence quenching of rhodamine B with the addition of i-PrI.

Visible-Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and Its Application to the Synthesis of a Key Fulvestrant Intermediate

Two efficient continuous flow iodoperfluoroalkylation methods are described: using 0.05 mol % perylene diimide (PDI) photocatalyst under 450 nm irradiation or substoichiometric triethylamine under 405 nm irradiation. These methods enable dramatically elevated productivity versus batch processes. The triethylamine-mediated method is explored mechanistically and in substrate scope. The gram-scale synthesis of an active pharmaceutical ingredient side chain is also reported in flow, via a photochemical iodoperfluoroalkylation followed by hydrogenolysis.

Sodium dithionite initiated addition of CF2Br2, CF3I and (CF3)2CFI to allylaromatics. Synthesis and the reactivity of 4-aryl-1,1-difluorodienes and 4-aryl-1,1-bis(trifluoromethyl)dienes

Sodium dithionite initiated addition of CF2Br2, CF3I and (CF3)2CFI to the terminal double bond of allylbenzenes and of (CF3)2CFI to allylpyridines in a MeCN/H2O system