1025097-10-2

Basic information

• Product Name: Cadazolid
• Synonyms: Cadazolid
• CAS NO: 1025097-10-2
• Molecular Formula: C₂₉H₂₉F₂N₃O₈
• Molecular Weight: 585.5526664
• EINECS: -0
• Product Categories: API
• Mol File: 1025097-10-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 832.6±65.0 °C(Predicted)
• Appearance: /
• Density: 1.539±0.06 g/cm3(Predicted)
• PKA: 6.44±0.41(Predicted)
• CAS DataBase Reference: Cadazolid(CAS DataBase Reference)
• NIST Chemistry Reference: Cadazolid(1025097-10-2)
• EPA Substance Registry System: Cadazolid(1025097-10-2)

Safety Data

• Hazardous Substances Data: 1025097-10-2(Hazardous Substances Data)

Usage

General Description

Cadazolid is a novel oxazolidinone compound that is being developed as a potential treatment for Clostridium difficile-associated diarrhea (CDAD) and other gastrointestinal infections. It works by inhibiting the protein synthesis in bacterial cells, leading to their death. Cadazolid has shown promise in clinical trials for its ability to effectively treat CDAD and prevent disease recurrence. Additionally, it has demonstrated a favorable safety profile with minimal side effects, making it a promising option for the treatment of gastrointestinal infections. As a result, Cadazolid is being further evaluated for its potential as a new therapeutic option for CDAD and other infectious diseases.

Upstream product

• 77211-75-7 benzyl 1-oxa-6-aza-spiro[2.5]octane-6-carboxylate 
• 1025097-53-3 4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-hydroxy-piperidine-1-carboxylic acid benzyl ester 
• 1025097-50-0 (R)‐3‐(3‐fluoro‐4‐hydroxyphenyl)‐5‐(hydroxymethyl)oxazolidin‐2‐one 
• 790703-49-0 (R)-3-(4-benzyloxy-3-fluoro-phenyl)-5-(hydroxymethyl)-oxazolidin-2-one 
• 138548-65-9 1-cyclopropyl-6-fluoro-4-oxo-7-(4-oxo-piperidin-1-yl)-1,4-dihydro-quinoline-3-carboxylic acid 
• 119489-54-2 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid boron diacetate 
• 138548-62-6 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(1,4-dioxa-8-azaspiro<4,5>decan-8-yl)-4-oxoquinoline-3-carboxylic acid 
• 1025097-55-5 (R)-3-[3-fluoro-4-(4-hydroxypiperidin-4-ylmethoxy)phenyl]-5-hydroxymethyloxazolidin-2-one 

Downstream Products

• 1025097-65-7 1-cyclopropyl-6-fluoro-7-{4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-hydroxy-piperidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester 
• 1025097-71-5 7-(4-{4-[(R)-5-(bis-benzyloxy-phosphoryloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 1025097-46-4 6-fluoro-7-{4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-hydroxy-piperidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 1025097-40-8 1-cyclopropyl-6-fluoro-7-{4-[2-fluoro-4-((R)-5-hydroxymethyl-2-oxo-oxazolidin-3-yl)-phenoxymethyl]-4-phosphonooxy-piperidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 1025097-18-0 1-cyclopropyl-6-fluoro-7-{4-[2-fluoro-4-((R)-2-oxo-5-phosphonooxymethyl-oxazolidin-3-yl)-phenoxymethyl]-4-hydroxy-piperidin-1-yl}-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 1025097-98-6 7-(4-{4-[(R)-5-(tert-butyldimethyl-silanyloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester 
• 1025097-69-1 7-(4-{4-[(R)-5-((S)-2-tert-butoxycarbonylamino-propionyloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 1025098-02-5 7-{4-[4-((R)-5-acetoxymethyl-2-oxo-oxazolidin-3-yl)-2-fluoro-phenoxymethyl]-4-phosphonooxy-piperidin-1-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester 
• 1025097-67-9 7-(4-{4-[(R)-5-((S)-2-tert-butoxycarbonylamino-propionyloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester 
• 1025097-79-3 7-(4-{4-[(R)-5-((S)-2-amino-propionyloxymethyl)-2-oxo-oxazolidin-3yl]-2-fluoro-phenoxymethyl}-4-hydroxy-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4oxo-1,4-dihydro-quinoline-3-carboxylic acid hydrochloride 
• 1025098-00-3 7-(4-(bis-benzyloxy-phosphoryloxy)-4-{4-[(R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-piperidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid benzyl ester 

Relevant articles and documents

NOVEL PROCESSES FOR PREPARING 5-HYDROXYMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES

The present invention relates to improved, commercially viable and industrially advantageous processes for the preparation of 5-Hydroxymethyl-oxazolidin-2-one derivatives or a pharmaceutically acceptable salt thereof using novel intermediates, in high yie