10259-08-2

Basic information

• Product Name: Cyclohexanol, 1-nitroso-, acetate (ester)
• CAS NO: 10259-08-2
• Molecular Formula: C8H13NO3
• Molecular Weight: 171.196
• Mol File: 10259-08-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Cyclohexanol, 1-nitroso-, acetate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanol, 1-nitroso-, acetate (ester)(10259-08-2)
• EPA Substance Registry System: Cyclohexanol, 1-nitroso-, acetate (ester)(10259-08-2)

Safety Data

• Hazardous Substances Data: 10259-08-2(Hazardous Substances Data)

Upstream product

• 100-64-1 cyclohexanone-oxime 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 41018-52-4 (4-bromophenyl)-λ³-iodanediyl diacetate 
• 108-24-7 acetic anhydride 
• 1122-60-7 1-nitrocyclohexane 
• 563-63-3 silver(I) acetate 
• 546-67-8 lead(IV) tetraacetate 

Downstream Products

• 105-60-2 caprolactam 
• 1264294-14-5 1-nitrosocyclohexyl pivalate 
• 100-64-1 cyclohexanone-oxime 
• 108-94-1 cyclohexanone 
• 13891-49-1 acetic acid-(1-nitro-cyclohexyl ester) 
• 13891-50-4 N-phenyl-N-(1-phenylcyclohexyl)hydroxylamine 
• 13972-59-3 N-Methyl-N-(1-methyl-cyclohexyl)-hydroxylamin 

Relevant articles and documents

[3,2]-Sigmatropic rearrangement of acyloxy nitronic acids into geminal acyloxy nitroso compounds

Acylation of secondary nitroalkanes is accompanied by [3,2]-sigmatropic rearrangement of acyloxy nitronic acids into geminal acyloxy nitroso compounds which are formed in preparative yields.

α-Acyloxynitroso dienophiles in [4+2] hetero Diels-Alder cycloadditions: mechanistic insights

α-Acyloxynitroso derivatives are a class of heterodienophiles leading to valuable 3,6-dihydro-1,2-oxazines or the corresponding aminoalcohols in good yields. The discovery that a β-oxygenated moiety led to a domino [4+2] cycloaddition/σN-O bond cleavage in the presence of a catalytic amount of Lewis acid was investigated in detail, through kinetic profiling of the reaction both in the absence and presence of a promoter. These studies showed that the role of the Lewis acid was to accelerate the σN-O bond cleavage thereby promoting a highly reproducible sequence. In addition, our preliminary results on an asymmetric version of this domino sequence are reported.

C-NITROSO-DERIVED NITROXYL DONORS

Active compounds of Formula (I) are described: wherein: R1 and R2 are each independently C1-C4 alkyl; or R1 and R2 together form a C2-C7 alkylene chain; and Z is a non-steroidal anti-inflammatory drug (NSAID); a