1026089-09-7

Basic information

• Product Name: 2-(4-bromo-2-methoxyphenyl)acetic acid
• Synonyms: 2-(4-bromo-2-methoxyphenyl)acetic acid;4-Bromo-2-methoxyphenylacetic acid
• CAS NO: 1026089-09-7
• Molecular Formula: C₉H₉BrO₃
• Molecular Weight: 245.06996
• Mol File: 1026089-09-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-bromo-2-methoxyphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromo-2-methoxyphenyl)acetic acid(1026089-09-7)
• EPA Substance Registry System: 2-(4-bromo-2-methoxyphenyl)acetic acid(1026089-09-7)

Safety Data

• Hazardous Substances Data: 1026089-09-7(Hazardous Substances Data)

Usage

General Description

2-(4-Bromo-2-methoxyphenyl)acetic acid is a chemical compound with the molecular formula C9H9BrO3. It is a derivative of acetic acid with a 4-bromo-2-methoxyphenyl group attached to the carbon atom. 2-(4-Bromo-2-methoxyphenyl)acetic acid is commonly used in organic synthesis and pharmaceutical research due to its potential biological activities and pharmacological properties. It has been studied for its potential as an anti-inflammatory and analgesic agent, as well as its potential in the treatment of various diseases and conditions. Additionally, it has been investigated for its potential as a building block in the synthesis of various organic compounds and pharmaceuticals.

Upstream product

• 43192-33-2 4-bromo-2-methoxybenzaldehyde 
• 1261878-59-4 4-bromo-2-methoxyphenylacetic acid methyl ester 
• 858523-37-2 2-(4-bromo-2-methoxyphenyl)acetonitrile 

Downstream Products

• 1423167-40-1 tert-butyl 4-((2-(3-methoxybiphenyl-4-yl)acetamido)methyl)benzylcarbamate 
• 1423167-13-8 C₂₂H₂₂N₂O₂ 
• 1261878-59-4 4-bromo-2-methoxyphenylacetic acid methyl ester 
• 1289626-24-9 2-(4-bromo-2-methoxyphenyl)ethan-1-ol 
• 1246766-09-5 2-(2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid 

Relevant articles and documents

HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE

This invention relates to novel compounds and pharmaceutical compositions comprising. Compounds of the invention useful as modulators of Rho-associated protein kinase (ROCK), for example ROCK1 and/or ROCK2 inhibitors. Methods of treatment employing the compounds are also contemplated by the present invention. The compounds of the invention are useful in treating ROCK mediated diseases.

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design

β-Secretase (BACE1), the enzyme responsible for the first and rate-limiting step in the production of amyloid-β peptides, is an attractive target for the treatment of Alzheimer's disease. In this study, we report the application of the de novo fragment-based molecular design program SPROUT to the discovery of a series of nonpeptide BACE1 inhibitors based upon a biphenylacetamide scaffold. The binding affinity of molecules based upon this designed molecular scaffold was increased from an initial BACE1 IC50 of 323 μM to 27 μM following the synthesis of a library of optimized ligands whose structures were refined using the recently developed SPROUT-HitOpt software. Although a number of inhibitors were found to exhibit cellular toxicity, one compound in the series was found to have useful BACE1 inhibitory activity in a cellular assay with minimal cellular toxicity. This work demonstrates the power of an in silico fragment-based molecular design approach in the discovery of novel BACE1 inhibitors.

ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS

This invention relates to substituted pyrrolidine compounds of the formula I wherein m, n, Ar, R1 and R2 are as defined herein. Methods of making the compounds and using the compounds are disclosed.