1026223-55-1

Basic information

• Product Name: C₁₁H₁₆O₄
• Synonyms: C₁₁H₁₆O₄
• CAS NO: 1026223-55-1
• Molecular Weight: 212.246
• Mol File: 1026223-55-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₆O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₆O₄(1026223-55-1)
• EPA Substance Registry System: C₁₁H₁₆O₄(1026223-55-1)

Safety Data

• Hazardous Substances Data: 1026223-55-1(Hazardous Substances Data)

Upstream product

• 120-74-1 (1S,2S,4S)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 

Downstream Products

• 344585-18-8 (1R,2S,4S)-bicyclo[2.2.1]heptane-2-isocyanate 

Relevant articles and documents

Novel Potassium-Channel Openers: Preparation and Pharmacological Evaluation of Racemic and Optically Active N-(6-Amino-3-pyridyl)-N'-bicycloalkyl-N"-cyanoguanidine Derivatives

The previous paper reported on the synthesis and pharmacological evaluation of N-(6-amino-3-pyridyl)-N'-bicycloalkyl-N"-cyanoguanidine derivatives, from among which three compounds were selected as potent potassium-channel openers. In the present study, selected compounds were tested for antagonism of potassium-induced contraction of rat aorta, hypotensive activity in normotensive rats, and diuretic activity in spontaneously hypertensive rats. This led to further evaluation of compound (+/-)-10 and selection of (+)-N-(6-amino-3-pyridyl)-N'-hept-2-yl>-N"-cyanoguanidine ((+)-10) (AL0670) for development as an antihypertensive agent. Although AL0670 is regarded as a pinacidil-type K+-channel opener, it showed different pharmacological and conformational profiles from pinacidil.