10263-66-8

Basic information

• Product Name: 2-CHLORO-N-(2-METHOXYETHYL)ACETAMIDE
• Synonyms: ASINEX-REAG BAS 02108713;AKOS BBS-00000933;2-CHLORO-N-(2-METHOXYETHYL)ACETAMIDE;2-chloro-N-(2-methoxyethyl)ethanamide
• CAS NO: 10263-66-8
• Molecular Formula: C₅H₁₀ClNO₂
• Molecular Weight: 151.59
• Mol File: 10263-66-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 288.5 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: /
• Density: 1.124 g/cm³
• PKA: 13.63±0.46(Predicted)
• CAS DataBase Reference: 2-CHLORO-N-(2-METHOXYETHYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(2-METHOXYETHYL)ACETAMIDE(10263-66-8)
• EPA Substance Registry System: 2-CHLORO-N-(2-METHOXYETHYL)ACETAMIDE(10263-66-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 10263-66-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-N-(2-methoxyethyl)acetamide is a distinct chemical compound which possesses the molecular formula C5H10ClNO2. It is characterized by particular features which include a chlorine atom, linked to one of the carbons in the compound, and a side chain comprising of a methoxyethyl group. 2-CHLORO-N-(2-METHOXYETHYL)ACETAMIDE falls under the category of organic compounds, specifically amides, which are derived from acids where one or more of the hydrogen atoms is replaced by an alkyl group. This chemical is typically involved in organic synthesis, potentially including medicinal or agricultural applications. It's critical to handle it properly due to the presence of chlorine which can be reactive.

Upstream product

• 79-04-9 chloroacetyl chloride 
• 109-85-3 2-methoxyethylamine 

Downstream Products

• 139892-83-4 (S)-<4-<2-<<2-hydroxy-3-(4-hydroxyphenoxy)propyl>amino>ethoxy>phenoxy>-N-(2-methoxyethyl)acetamide 
• 133025-88-4 N-(2-methoxyethyl)<4-<2-(benzylamino)ethoxy>phenoxy>acetamide 

Relevant articles and documents

Inhibition of tumor cell growth by a specific 6-phosphofructo-2-kinase inhibitor, N-bromoacetylethanolamine phosphate, and its analogues.

The high rate of glycolysis despite the presence of oxygen and mitochondria in tumor cells implies an important role for this process in cell division. The rate of glycolysis is assumed to be dependent on the cellular concentration of fructose 2,6-bisphosphate, the concentration of which in turn depends on a bifunctional enzyme and the ratio of this enzyme's 6-phosphofructo-2-kinase versus its fructose 2,6-bisphosphatase activities. To prove the hypothesis that inhibition of glycolysis in tumor cells by 6-phosphofructo-2-kinase inhibitors would cause inhibition of tumor cell proliferation, ten N-bromoacetylethanolamine phosphate analogues were designed, synthesized, and tested. They were screened for their activities against various human tumor cell lines to study the effects of inhibition of glycolysis on cell proliferation. The relationship between the structure of these compounds and their inhibitory activity on cell proliferation was also discussed. It was found that the activity of N-(2-methoxyethyl)-bromoacetamide, N-(2-ethoxyethyl)-bromoacetamide, and N-(3-methoxypropyl)-bromoacetamide was comparable to that of the positive control AraC. These three inhibitors showed in vivo anticancer effects in P388 transplant BDF1 mice.

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