1027102-02-8

Basic information

• Product Name: 2-[[[(ethoxycarbonyl)amino]thioxomethyl]amino]-3-(4-chlorophenyl)-propionic acid methyl ester
• Synonyms: 2-[[[(ethoxycarbonyl)amino]thioxomethyl]amino]-3-(4-chlorophenyl)-propionic acid methyl ester
• CAS NO: 1027102-02-8
• Molecular Weight: 344.819
• Mol File: 1027102-02-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[[[(ethoxycarbonyl)amino]thioxomethyl]amino]-3-(4-chlorophenyl)-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[[[(ethoxycarbonyl)amino]thioxomethyl]amino]-3-(4-chlorophenyl)-propionic acid methyl ester(1027102-02-8)
• EPA Substance Registry System: 2-[[[(ethoxycarbonyl)amino]thioxomethyl]amino]-3-(4-chlorophenyl)-propionic acid methyl ester(1027102-02-8)

Safety Data

• Hazardous Substances Data: 1027102-02-8(Hazardous Substances Data)

Upstream product

• 7424-00-2 DL-Phe(4Cl) 
• 14173-40-1 2-amino-3-(4-chlorophenyl)propionic acid methyl ester hydrochloride 
• 16182-04-0 Ethoxycarbonyl isothiocyanate 

Downstream Products

• 1027102-03-9 3-(4-chlorophenyl)-2-thioureido-propionic acid 
• 1027102-04-0 3-(4-chlorophenyl)-2-[4-(3,5-difluoro-phenyl)-thiazol-2-ylamino]-propionic acid 
• 1094765-51-1 3-(4-chlorophenyl)-2-(4-(8-aminooctylphenyl)thiazol-2-ylamino)propionic acid 
• 1094765-49-7 3-(4-chlorophenyl)-2-(4-(8-azidooctylphenyl)thiazol-2-ylamino)propionic acid 

Relevant articles and documents

Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth

Galactofuranose (Galf) residues are fundamental components of the cell wall of mycobacteria. A key enzyme, UDP-galactopyranose mutase (UGM), that participates in Galf incorporation mediates isomerization of UDP-Galf from UDP-galactopyranose (UDP-Galp). UGM is of special interest as a therapeutic target because the gene encoding it is essential for mycobacterial viability and there is no comparable enzyme in humans. We used structure-activity relationships and molecular design to devise UGM inhibitors. From a focused library of synthetic aminothiazoles, several compounds that block the UGM from Klebsiella pneumoniae or Mycobacterium tuberculosis were identified. These inhibitors block the growth of M. smegmatis. Copyright