1027319-73-8

Basic information

• Product Name: ((S)-2-Hydroxy-1-phenyl-ethylamino)-acetic acid ethyl ester
• Synonyms: ((S)-2-Hydroxy-1-phenyl-ethylamino)-acetic acid ethyl ester
• CAS NO: 1027319-73-8
• Molecular Weight: 223.272
• Mol File: 1027319-73-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ((S)-2-Hydroxy-1-phenyl-ethylamino)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-2-Hydroxy-1-phenyl-ethylamino)-acetic acid ethyl ester(1027319-73-8)
• EPA Substance Registry System: ((S)-2-Hydroxy-1-phenyl-ethylamino)-acetic acid ethyl ester(1027319-73-8)

Safety Data

• Hazardous Substances Data: 1027319-73-8(Hazardous Substances Data)

Upstream product

• 20989-17-7 (2S)-2-phenylglycinol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1015788-00-7 (4S)-N-(ethoxycarbonylmethyl)-4-phenyloxazolidine 
• 625824-32-0 (3S,5S)-2,3,5,6-tetrahydro-3-(4-bromobutyl)-5-phenyl-N-(benzyloxycarbonyl)-4H-1,4-oxazine-2-one 
• 625824-28-4 (3S,5S)-2,3,5,6-tetrahydro-3-(3-butenyl)-5-phenyl-N-(benzyloxycarbonyl)-4H-1,4-oxazine-2-one 
• 147700-91-2 (5S)-2,3,5,6-tetrahydro-5-phenyl-N-(benzyloxycarbonyl)-4H-1,4-oxazin-2-one 

Relevant articles and documents

An expedient route to the glycine templates (R)- or (S)-N-Cbz-5-phenyl-1,4-oxazin-2-one

An economical and practical route to the title compounds is described. The three step, essentially 'one pot' sequence proceeds in overall yields of up to 80% without the need for chromatography of intermediate isolation.

Highly diastereoselective alkylation of the Dellaria oxazinone template with bifunctional electrophiles

This study investigates the efficiency of alkylation of the Dellaria oxazinone glycinate template with sensitive bifunctional electrophiles. In addition to improved access to the template, triflate/halide bifunctional combinations provided good yields (85-93%) of highly diastereoselective alkylation products.