1027493-30-6

Basic information

• Product Name: 2-[5-bromo-4-bromomethyl-3-(4-chloro-benzoyl)-thiophen-2-yl]-isoindole-1,3-dione
• Synonyms: 2-[5-bromo-4-bromomethyl-3-(4-chloro-benzoyl)-thiophen-2-yl]-isoindole-1,3-dione
• CAS NO: 1027493-30-6
• Molecular Weight: 539.631
• Mol File: 1027493-30-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[5-bromo-4-bromomethyl-3-(4-chloro-benzoyl)-thiophen-2-yl]-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[5-bromo-4-bromomethyl-3-(4-chloro-benzoyl)-thiophen-2-yl]-isoindole-1,3-dione(1027493-30-6)
• EPA Substance Registry System: 2-[5-bromo-4-bromomethyl-3-(4-chloro-benzoyl)-thiophen-2-yl]-isoindole-1,3-dione(1027493-30-6)

Safety Data

• Hazardous Substances Data: 1027493-30-6(Hazardous Substances Data)

Upstream product

• 1027493-29-3 2-[5-bromo-3-(4-chloro-benzoyl)-4-methyl-thiophen-2-yl]-isoindole-1,3-dione 

Downstream Products

• 1027493-31-7 2-[5-bromo-3-(4-chloro-benzoyl)-4-(4-phenyl-piperazin-1-ylmethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-21-9 2-[5-bromo-3-(4-chlorobenzoyl)-4-(phenylthiomethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-20-8 2-[5-bromo-3-(4-chlorobenzoyl)-4-(4-(fluoro)phenyloxymethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-19-5 2-[5-bromo-3-(4-chlorobenzoyl)-4-(4-(isopropyl)phenyloxymethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-18-4 2-[5-bromo-3-(4-chlorobenzoyl)-4-(4-(methyl)phenyloxymethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-17-3 2-[5-bromo-3-(4-chlorobenzoyl)-4-(phenyloxymethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-66-2 (2-amino-5-bromo-4-((N,N-diallylamino)methyl)-thiophen-3-yl)(4-chlorophenyl)methanone 
• 1456735-02-6 2-[5-bromo-3-(4-chlorobenzoyl)-4-(N,N-diisopropylaminomethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-01-5 2-[5-bromo-3-(4-chlorobenzoyl)-4-(N,N-dipropylaminomethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-00-4 2-[5-bromo-3-(4-chlorobenzoyl)-4-(N-benzyl-N-methylaminomethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-16-2 2-[5-bromo-3-(4-chlorobenzoyl)-4-(N-methyl-N-(4-trifluoromethylphenyl)-aminomethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-15-1 2-[5-bromo-3-(4-chlorobenzoyl)-4-(N-(4-chlorophenyl)-N-methylaminomethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-14-0 2-[5-bromo-3-(4-chlorobenzoyl)-4-(N-(4-fluorophenyl)-N-methylaminomethyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 1456735-13-9 2-[5-bromo-3-(4-chlorobenzoyl)-4-(N'-ethyl-N-phenyl-aminomethyl)-thiophen-2-yl]-isoindole-1,3-dione 

Relevant articles and documents

ALLOSTERIC ENHANCERS OF THE A1 ADENOSINE RECEPTOR

The present invention provides compounds of formula (I) wherein W, R1, R5 and R6 have a meaning as defined herein in the specification. The compounds of formula (I) are allosteric enhancers of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor. Accordingly, the compounds of formula (I) may be employed for treatment of pain, in particular, chronic pain such as neuropathic pain, and inflammatory pain, cardiac disease or disorder such as cardiac disarrhythmias, e.g., peroxysmal supraventricular tachycardia, angina, myocardial infarction and stroke, neurological disease or injury, sleep disorders, epilepsy and depression.

ALLOSTERIC MODULATORS OF THE A1 ADENOSINE RECEPTOR

The present invention provides compounds of formula (I) wherein R1, R2, R3, R4 and Q have a meaning as defined herein in the specification. The compounds of formula (I) are allosteric modulators of the A1 adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the A1 adenosine receptor. Accordingly, the compounds of formula (I) may be employed for treatment of pain, in particular, chronic pain such as neuropathic pain; cardiac disease or disorder such as cardiac disarrhythmias, e.g., peroxysmal supraventricular tachycardia, angina, myocardial infarction and stroke; neurological disease or injury; sleep disorder; epilepsy; and depression.