1027909-97-2Relevant articles and documents
Design and synthesis of modified quinolones as antitumoral acridones
Tabarrini, Oriana,Cecchetti, Violetta,Fravolini, Arnaldo,Nocentini, Giuseppe,Barzi,Sabatini, Stefano,Miao, Hua,Sissi, Claudia
, p. 2136 - 2144 (2007/10/03)
The bacterial topoisomerase II (DNA gyrase) and the mammalian topoisomerase II represent the cellular targets for quinolone antibacterials and a wide variety of anticancer drugs, respectively. In view of the mechanistic similarities and sequence homologie