102921-93-7Relevant articles and documents
Synthesis of Pyrimidin-2-one Nucleosides as Acid-Stable Inhibitors of Cytidine Deaminase
Kim, Chong-Ho,Marquez, Victor E.,Mao, David T.,Haines, David R.,McCormack, John J.
, p. 1374 - 1380 (2007/10/02)
One of the problems encountered in the use of the tetrahydrouridine (THU, 2) and saturated 2-oxo-1,3-diazepine nucleosides as orally administered cytidine deaminase (CDA) inhibitors is their acid instability.Under acid conditions these compounds are rapid