102940-86-3 Usage
Description
2-Chloro-3-fluorobenzoic acid is an organic compound characterized by its white powder form. It is a synthetic intermediate with significant applications in the pharmaceutical industry due to its ability to be used in the synthesis of various compounds with biological activities.
Uses
Used in Pharmaceutical Industry:
2-Chloro-3-fluorobenzoic acid is used as a synthetic intermediate for the development of aminobenzhydrol derivatives containing pendant cyclic amines. These derivatives act as inhibitors of squalene synthase and cholesterol synthase, which are key enzymes in the biosynthesis of cholesterol. Inhibition of these enzymes can lead to the reduction of cholesterol levels, making this compound a valuable contributor to the treatment of hypercholesterolemia and related conditions.
Additionally, 2-chloro-3-fluorobenzoic acid is used as a synthetic intermediate to prepare aryl aminopyrazole benzamides. These compounds serve as oral non-steroidal selective glucocorticoid receptor agonists, which can be beneficial in the treatment of various inflammatory and immune disorders. The selective nature of these agonists allows for targeted therapy with potentially fewer side effects compared to traditional glucocorticoids.
Check Digit Verification of cas no
The CAS Registry Mumber 102940-86-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,9,4 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 102940-86:
(8*1)+(7*0)+(6*2)+(5*9)+(4*4)+(3*0)+(2*8)+(1*6)=103
103 % 10 = 3
So 102940-86-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H4ClFO2/c8-6-4(7(10)11)2-1-3-5(6)9/h1-3H,(H,10,11)
102940-86-3Relevant articles and documents
Regiospecific Synthesis of Mixed 2,3-Dihalobenzoic Acids and Related Acetophenones via Ortho-Metalation Reactions
Moyroud, Joel,Guesnet, Jean-Luc,Bennetau, Bernard,Mortier, Jacques
, p. 881 - 884 (1995)
Concise general routes to mixed 2,3-dihalobenzoic acids and related acetophenones-based on directed ortho-metalation and ipso-desilylation reactions are described.
METHOD OF TREATMENT
-
Page/Page column 13, (2009/04/25)
This invention relates to the use of a sulfonamide substituted diphenyl urea compound to treat cystic fibrosis, or the symptoms associated with cystic fibrosis.
NEW MEDICAL USE OF TRIAZINE DERIVATIVES
-
Page/Page column 32, (2008/06/13)
-
