1029605-66-0

Basic information

• Product Name: 7-hydroxy-3-(4-trimethylsilanyloxy-phenyl)-8-(3,4,5-tris-trimethylsilanyloxy-6-trimethylsilanyloxy-methyl-tetrahydro-pyran-2-yl)-chromen-4-one
• CAS NO: 1029605-66-0
• Molecular Weight: 777.294
• Mol File: 1029605-66-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-hydroxy-3-(4-trimethylsilanyloxy-phenyl)-8-(3,4,5-tris-trimethylsilanyloxy-6-trimethylsilanyloxy-methyl-tetrahydro-pyran-2-yl)-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-3-(4-trimethylsilanyloxy-phenyl)-8-(3,4,5-tris-trimethylsilanyloxy-6-trimethylsilanyloxy-methyl-tetrahydro-pyran-2-yl)-chromen-4-one(1029605-66-0)
• EPA Substance Registry System: 7-hydroxy-3-(4-trimethylsilanyloxy-phenyl)-8-(3,4,5-tris-trimethylsilanyloxy-6-trimethylsilanyloxy-methyl-tetrahydro-pyran-2-yl)-chromen-4-one(1029605-66-0)

Safety Data

• Hazardous Substances Data: 1029605-66-0(Hazardous Substances Data)

Upstream product

• 3681-99-0 puerarin 
• 13435-12-6 N-Trimethylsilylacetamide 

Downstream Products

• 1029605-72-8 7-hydroxy-8-((6-hydroxymethyl)-3,4,5-tris-trimethylsilanyloxy-tetrahydro-pyran-2-yl)-3-(4-hydroxy-phenyl)-chromen-4-one 
• 1029605-74-0 6-[7-hydroxy-3-(4-hydroxy-phenyl)-4-oxo-4H-chromen-8-yl]-3,4,5-tris-trimethyl-silanyloxy-tetrahydro-pyran-2-carbaldehyde 

Relevant articles and documents

Synthesis of tritium-labeled puerarin - A potential antidipsotropic agent

Puerarin 1 (8-β-D-Glucopyranosyl-4′-7-dihydroxyisoflavone, NPI-031G) is the major isoflavone C-glycoside isolated from Pueraria lobata, a traditional Chinese medicine widely used for the treatment of alcohol intoxication. In order to understand the mode of action of puerarin in the reward pathway of the central nervous system and to study its bioavailability and pharmacokinetics, we developed a synthetic route for the preparation of tritium-labeled puerarin. The key intermediate 4 was obtained by trimethylsilyl protection of all hydroxyl groups followed by selective deprotection. The corresponding aldehyde 5 was obtained through the subsequent oxidation of the primary alcohol. Standard NaB[3H]4 reduction and hydrolysis produced the tritium-labeled puerarin 6. Copyright