103-00-4Relevant articles and documents
One-Pot Synthesis of Disubstituted Urea from Carbon Dioxide, Propylene Oxide, and Amines Catalyzed by Imidazolium-Tetraiodoindate
Son, Guang Meang,Truong, Cong Chien,Mishra, Dinesh Kumar,Mishra, Vivek,Kim, Yong Jin
, p. 174 - 183 (2018)
In this article, synthesis of 1,3-disubstituted urea (DSU) from three component reagent systems comprising amine, carbon dioxide, and propylene oxide is described. DSU is synthesized in the presence of a variety of ionic liquids (ILs) with/without promoters. Among used ILs, 1-butyl-3-methylimidazolium tetraiodoindateIII (represented as [Bmim][InI4]) is found to give the highest DSU product. A serious experiment clearly indicates that the tetraiodoindate anion plays an important role for the selective production of the DSU. Based on the in situ infrared spectroscopic studies, a plausible reaction mechanism for producing dicyclohexylurea from cyclohexylamine is proposed. The synthesis and characterization of [Bmim][InI4] are given in details. Moreover, the effect of reaction variables such as time, temperature, pressure, and the molar ratio of substrate to catalyst is also studied.
Process for Preparing Disubstituted Urea and Carbamate Compounds from Amines, Carbon Dioxide, and Epoxides
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Paragraph 0061; 0062; 0063, (2015/05/26)
The present disclosure relates to a method for preparing a disubstituted urea and carbamate compounds simultaneously through a one-pot reaction of an amine, carbon dioxide and an alkylene oxide compound in the presence of an ionic liquid-based complex catalyst system containing indium. In accordance with the present disclosure, a disubstituted urea and carbamate compounds can be prepared simultaneously at high yield. In addition, the ionic liquid-based catalyst containing indium according to the present disclosure is economical because it can be reused several times.
Cyclohexylamines
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Paragraph 0217, (2013/05/08)
The present application provides novel compounds and methods for preparing and using these compounds. These compounds are useful in treating pain, itch, overactive bladder and/or interstitial cystitis in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) and a TRPV1 receptor activator. In one embodiment, the TRPV1 receptor activator is lidocaine.