103-03-7 Usage
Description
1-Phenylsemicarbazide is an organic compound that serves as an important intermediate in the synthesis of various chemical compounds, particularly in the pharmaceutical industry. It is known for its ability to participate in cyclocondensation reactions, which are crucial for the creation of a range of alkyl, aryl, and heteroaryl substituted pyrazoles and their analogs.
Uses
Used in Pharmaceutical Industry:
1-Phenylsemicarbazide is used as a key intermediate for the synthesis of various alkyl(aryl/heteroaryl) substituted 3-trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs. These compounds have potential applications in the development of new drugs and therapeutic agents, making 1-Phenylsemicarbazide a valuable component in the pharmaceutical industry.
Used in the Synthesis of Antipyretic Dellepsoids D26:
1-Phenylsemicarbazide is used as a starting material in the production of Antipyretic Dellepsoids D26, a brand name for a group of compounds with antipyretic (fever-reducing) properties. The compound plays a crucial role in the development of these therapeutic agents, which can be used to alleviate symptoms of fever and inflammation in patients.
World Health Organization (WHO)
Phenicarbazide, which has analgesic and antipyretic activity, was
introduced in the 1970s. It has been withdrawn in at least one country on grounds
of its adverse effect profile and it appears to have fallen into disuse in others.
Purification Methods
Crystallise it from water and dry it in a vacuum over KOH. [Beilstein 15 H 287, 15 II 106, 15 III 184, 15 IV 180.]
Check Digit Verification of cas no
The CAS Registry Mumber 103-03-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 103-03:
(5*1)+(4*0)+(3*3)+(2*0)+(1*3)=17
17 % 10 = 7
So 103-03-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H7N3O/c8-7(11)10-9-6-4-2-1-3-5-6/h1-5H,(H2,8,11)
103-03-7Relevant articles and documents
Microwave-assisted synthesis of N-monosubstituted urea derivatives
De Luca, Lidia,Porcheddu, Andrea,Giacomelli, Giampaolo,Murgia, Irene
scheme or table, p. 2439 - 2442 (2010/11/18)
An easy and rapid procedure for the preparation of N-monosubstituted ureas via reaction between potassium cyanate and a wide range of amines is described. The procedure was performed under microwave irradiation using water as solvent. This methodology is particularly attractive since it provides ureas in high yield and purity. Georg Thieme Verlag Stuttgart · New York.
Gene delivery compounds
-
, (2008/06/13)
Compounds having the structure: wherein R1, R2 and R3 are each independently a C0-12 substituent selected from the group consisting of: hydrogen, a heteroatom, alkyl, alkenyl, alkynyl, heteroatom substituted alkyl, heteroatom substituted alkenyl, heteroatom substituted alkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl; where the heteroatom is selected from the group consisting of: N, O and S; and where (A) is a single or double bond between N and R3. Further the C0-12 substituent is linear, branched or cyclic and optionally includes a pendant moiety selected from the group consisting of: carbonyl, hydroxyl, carboxyl, amine, thiol, thioester, thioether, phosphate, alkoxy, aryl, arylalkyl, sulfonamide and alkyl halide. Further, compounds 6883, 6898, 6975, 7036, 7064 and 8496 are provided. A process is provided for activating gene transfer in a subject by administering a pharmaceutically effective amount of a gene transfer activating compound to a subject and delivering pharmaceutically effective amount of a vector containing a nucleic so that the nucleic acid is transcribed in a target cell of the subject. A process for activating gene transfer to a cell is provided. A kit for activating gene transfer is provided.
