103011-38-7

Basic information

• Product Name: 3-(1,3-DIOXOLAN-2-YL)THIOPHENE-2-SULFONYL CHLORIDE
• Synonyms: 3-(1,3-DIOXOLAN-2-YL)THIOPHENE-2-SULFONYL CHLORIDE;3-(1,3-DIOXOLAN-2-YL)THIOPHENE-2-SULPHONYL CHLORIDE;3-(1,3-Dioxolan-2-yl)thiophene-2-sulphonyl chloride 97%;2-[2-(Chlorosulphonyl)thien-3-yl]-1,3-dioxolane, 2-(Chlorosulphonyl)-3-(1,3-dioxolan-2-yl)thiophene;3-(1,3-Dioxolan-2-yl)thiophene-2-sulphonylchloride97%
• CAS NO: 103011-38-7
• Molecular Formula: C₇H₇ClO₄S₂
• Molecular Weight: 254.71
• Mol File: 103011-38-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 93 °C
• Boiling Point: 365.3°Cat760mmHg
• Flash Point: 174.7°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 3-(1,3-DIOXOLAN-2-YL)THIOPHENE-2-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3-DIOXOLAN-2-YL)THIOPHENE-2-SULFONYL CHLORIDE(103011-38-7)
• EPA Substance Registry System: 3-(1,3-DIOXOLAN-2-YL)THIOPHENE-2-SULFONYL CHLORIDE(103011-38-7)

Safety Data

• Hazardous Substances Data: 103011-38-7(Hazardous Substances Data)

Usage

General Description

3-(1,3-Dioxolan-2-yl)thiophene-2-sulfonyl chloride is a chemical compound that belongs to the class of sulfonyl chlorides. It is used in organic synthesis as a reagent for introducing the sulfonyl chloride functional group into various organic molecules. It is also employed in the preparation of pharmaceuticals and agrochemicals. The compound has a heterocyclic thiophene ring and a dioxolane ring, which gives it unique reactivity and properties. It is important to handle this compound with care and follow proper safety precautions due to its reactivity and potential hazards.

InChI:InChI=1/C7H7ClO4S2/c8-14(9,10)7-5(1-4-13-7)6-11-2-3-12-6/h1,4,6H,2-3H2

Upstream product

• 13250-82-3 2-(thiophen-3-yl)-1,3-dioxolane 

Downstream Products

• 224313-73-9 3-hydroxymethyl-N-methoxymethyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide 
• 224313-55-7 3-(hydroxymethyl)-N-(3-methoxyphenyl)-2-thiophenesulfonamide 
• 224314-51-6 3-formyl-N-(3-methoxyphenyl)-2-thiophenesulfonamide 
• 171273-13-5 3-(4-morpholinylmethyl)-2-[4-(4-morpholinyl)phenyl]-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide 
• 739354-85-9 2-(3,4-dimethoxy-phenyl)-3-morpholin-4-ylmethyl-1,1-dioxo-1,2-dihydro-1λ⁶-thieno[3,2-e][1,2]thiazine-6-sulfonic acid amide 
• 171272-90-5 2-(4-methoxy-benzyl)-3-morpholin-4-ylmethyl-1,1-dioxo-1,2-dihydro-1λ⁶-thieno[3,2-e][1,2]thiazine-6-sulfonic acid amide 
• 286958-83-6 3-hydroxymethyl-2-(4-morpholin-4-yl-phenyl)-1,1-dioxo-1,2-dihydro-1λ⁶-thieno[3,2-e][1,2]thiazine-6-sulfonic acid amide 
• 404034-54-4 2-(3-methoxy-phenyl)-3-morpholin-4-ylmethyl-1,1-dioxo-1,2-dihydro-1λ⁶-thieno[3,2-e][1,2]thiazine-6-sulfonic acid amide 
• 738570-09-7 3-[(2-hydroxy-ethylamino)-methyl]-2-(3-methoxy-phenyl)-1,1-dioxo-1,2-dihydro-1λ⁶-thieno[3,2-e][1,2]thiazine-6-sulfonic acid amide 
• 742047-72-9 3-cyclopropylaminomethyl-2-(3-methoxy-propyl)-1,1-dioxo-1,2-dihydro-1λ⁶-thieno[3,2-e][1,2]thiazine-6-sulfonic acid amide 

Relevant articles and documents

2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: Synthesis, carbonic anhydrase inhibition and evaluation in the rabbit

Novel non-chiral 2H-thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6- sulfonamide 1,1-dioxides were synthesized for evaluation as potential candidates for the treatment of glaucoma. All of the compounds prepared were potent high affinity inhibitors of human carbonic anhydrase II, K(i) 50 values ranging from 4.25 to 73.6 nM. Of the compounds evaluated for their ability to lower intraocular pressure in naturally hypertensive Dutch-belted rabbits, 5a, 17a3, 17b1, 17b2, 17h2 and 17i1 showed significant efficacy (> 20% decrease) in this model following topical ocular administration. (C) 2000 Elsevier Science Ltd.

Herbicidal acetals and ketals

Novel furan- and thiophenesulfonamides such as 3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3-5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide and N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide are highly active pre-emergent and/or post-emergent herbicides.