10310-21-1Relevant articles and documents
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Balsinger,Montgomery
, p. 1573 (1960)
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A new method to synthesize famciclovir
Luo, Lei,Chen, Guorong,Li, Yuanchao
, p. 2803 - 2808 (2008)
A new and efficient method has been reported for the synthesis of 2-amino-9-[4-acetoxy-3-(acetoxymethyl)butyl-1-yl]purine(famciclovir)starting from guanine. The route involves chlorination of guanine, optimized Mitsunobu reaction, coupling with diethyl malonate, hydrogenation, reduction and esterification,and the overall yield is about 29%. This method does not require any form of chromatographic purification to give pure famciclovir, and it is an industrially viable manufacturing process for this drug. The Japan Institute of Heterocyclic Chemistry.
Synthesis method of 2-amino-6-chloroguanine
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Paragraph 0052-0057, (2021/08/11)
The invention provides a synthesis method of 2-amino-6-chloroguanine, the synthesis method comprises the following steps: synthesizing 2-amino-6-chloroguanine; according to the method disclosed by the invention, a route of a 2, 4, 5-triamino-6-chloropyrimidine intermediate is not adopted, but 4-chloro-5, 6-dinitropyrimidine-2-amine is taken as an intermediate, and 2-amino-6-chloroguanine is obtained by cyclization on the basis of the intermediate. The synthesis method has few steps, each step is easy to carry out, and the product is high in yield and high in purity, so that the total yield of the 2-amino-6-chloroguanine is relatively high; the method is suitable for industrial production of the 2-amino-6-chloroguanine, and has a wide commercial prospect.
Synthetic method 2 -amino -6 - chloropurine
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Paragraph 0048-0075, (2021/08/25)
The invention provides a synthetic method of 2 - amino -6 - chloropurine, and belongs to the field of organic synthesis. The synthesis method provided by the invention comprises the following steps: adding 2 -acetyl-6-hydroxypurine into the reaction container. The product and comprises hexachloroacetone, organic base A chloride, heating reflux reaction 2h - 48h, distillation to remove dimethyl sulfoxide, adding alkali liquor pH, reacting 1h - 12h, adjusting 7.0 - 7.5 to 2 - and separating and purifying to obtain the amino -6 - chloropurine of the target product. The nitrogen-containing phosphorus-containing reagent is greatly reduced, the emission of nitrogen-containing phosphorus-containing wastewater is reduced correspondingly, and large-scale process production is facilitated.