103176-56-3

Basic information

• Product Name: 4-[((E)-Octa-2,7-dienyl)oxy]-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-benzamide
• CAS NO: 103176-56-3
• Molecular Weight: 447.494
• Mol File: 103176-56-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[((E)-Octa-2,7-dienyl)oxy]-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[((E)-Octa-2,7-dienyl)oxy]-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-benzamide(103176-56-3)
• EPA Substance Registry System: 4-[((E)-Octa-2,7-dienyl)oxy]-N-[3-(1H-tetrazol-5-yl)-2,3-dihydro-benzo[1,4]dioxin-5-yl]-benzamide(103176-56-3)

Safety Data

• Hazardous Substances Data: 103176-56-3(Hazardous Substances Data)

Upstream product

• 92747-32-5 (E)-8-chloro-octa-1,6-diene 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 110683-63-1 p-<2(E),7-octadienyloxy>benzoic acid 
• 110683-20-0 8-amino-2-tetrazol-5-yl-1,4-benzodioxan 

Relevant articles and documents

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.