103203-47-0

Basic information

• Product Name: 1-(4-ethyl-3-nitrophenyl)ethanone
• Synonyms: 1-(4-ethyl-3-nitrophenyl)ethanone
• CAS NO: 103203-47-0
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.19924
• EINECS: -0
• Mol File: 103203-47-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-ethyl-3-nitrophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-ethyl-3-nitrophenyl)ethanone(103203-47-0)
• EPA Substance Registry System: 1-(4-ethyl-3-nitrophenyl)ethanone(103203-47-0)

Safety Data

• Hazardous Substances Data: 103203-47-0(Hazardous Substances Data)

Usage

General Description

1-(4-ethyl-3-nitrophenyl)ethanone, also known as p-Nitropropacetamol, is a chemical compound with the molecular formula C11H13NO3. It is a derivative of acetaminophen and has a nitro substitution on the para position of the phenyl ring. 1-(4-ethyl-3-nitrophenyl)ethanone is commonly used as an analgesic and antipyretic drug, similar to acetaminophen, and is marketed under various trade names. It has been shown to be effective in the treatment of moderate to severe pain and fever, and its mechanism of action is believed to be similar to acetaminophen, involving the inhibition of prostaglandin synthesis in the central nervous system. However, p-Nitropropacetamol also has its own distinct properties and pharmacokinetics, and is metabolized into its active form, p-aminophenol, in the body.

Upstream product

• 937-30-4 4-ethylacetophenone 

Downstream Products

• 721884-94-2 2-ethyl-5-propyl-aniline 
• 857420-20-3 1-[4-ethyl-3-(2,5-dimethyl-pyrrol-1-yl)-phenyl]-propan-1-one 
• 857229-61-9 1-(4-ethyl-3-amino-phenyl)-propan-1-one 
• 103030-61-1 1-(4-ethyl-3-amino-phenyl)-ethanone 
• 80427-50-5 1-amino-2,5-diethylbenzene 

Relevant articles and documents

Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships

Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.

CINNOLINE AND QUINAZOLINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS

The present invention is directed to cinnoline and quinazoline compounds of formula (I) that are PDE10 inhibitors, pharmaceutical compounds containing the same and processes for preparing the same. The invention is also directed to methods of treating diseases mediated by PDE10 enzyme such as obesity, non-insulin dependent diabetes, schizophrenia or bipolar disorder, obsessive-compulsive disorder, and the like.