103260-65-7

Basic information

• Product Name: 4-Methoxy-1H-indole-2-carboxylic acid
• Synonyms: 4-METHOXYINDOLE-2-CARBOXYLIC ACID;4-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID;4-METHOXY-2-INDOLECARBOXYLIC ACID;AKOS JY2082663;IFLAB-BB F2137-0008;4-Methoxyindole-2-CarboxylicAcid99%;4-Methoxyindole-2-carboxylic acid, 97+%;4-Methoxy-1H-indol-2-carboxylic acid
• CAS NO: 103260-65-7
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191.18
• Product Categories: Indoles and derivatives;Indole
• Mol File: 103260-65-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 234-235 °C
• Boiling Point: 447.6 °C at 760 mmHg
• Flash Point: 224.5 °C
• Appearance: /
• Density: 1.381 g/cm³
• Vapor Pressure: 8.54E-09mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.52±0.30(Predicted)
• CAS DataBase Reference: 4-Methoxy-1H-indole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-1H-indole-2-carboxylic acid(103260-65-7)
• EPA Substance Registry System: 4-Methoxy-1H-indole-2-carboxylic acid(103260-65-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 103260-65-7(Hazardous Substances Data)

Usage

General Description

4-Methoxy-1H-indole-2-carboxylic acid is a chemical compound that belongs to the class of indole carboxylic acids. It is commonly used as a building block in organic synthesis and pharmaceutical research. 4-Methoxy-1H-indole-2-carboxylic acid has an indole core structure with a carboxylic acid group and a methoxy substituent at the 4-position. It is known for its potential biological activities, including anti-inflammatory and antioxidant properties. Its structure and properties make it a valuable tool for the development of new drugs and bioactive molecules.

InChI:InChI=1/C10H9NO3/c1-14-9-4-2-3-7-6(9)5-8(11-7)10(12)13/h2-5,11H,1H3,(H,12,13)

Upstream product

• 301155-92-0 3-(2-Methoxy-6-nitro-phenyl)-2-oxo-propionic acid ethyl ester 
• 4837-88-1 6-methoxy-2-nitrotoluene 
• 135-02-4 ortho-anisaldehyde 
• 143702-35-6 (Z)-2-azido-3-(2-methoxyphenyl)acrylic acid methyl ester 
• 111258-23-2 methyl 4-methoxy-1H-indole-2-carboxylate 
• 4837-89-2 pyruvic acid 

Downstream Products

• 43142-25-2 ethyl 4-methoxy-indole-2-carboxylate 
• 4837-90-5 4-methoxy-1H-indole 
• 1210357-88-2 C₂₂H₂₃N₃O₆ 
• 870153-29-0 PF-00835231 
• 870153-29-0 N-[(1R)-1-[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxopyrrolidin-3-yl]methyl]propyl]carbamoyl]-3-methyl-butyl]-4-methoxy-1H-indole-2-carboxamide 
• 1471484-62-4 N-((S)-1-(((S)-1-(benzo[d]thiazol-2-yl)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methoxy-1H-indole-2-carboxamide 
• 1429473-92-6 3-((4-chlorophenyl)thio)-4-methoxy-1H-indole-2-carboxylic acid 
• 138863-11-3 1-[4-Methoxyindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine 
• 111258-25-4 methyl 4-methoxy-1-methyl-1H-indole-2-carboxylate 

Relevant articles and documents

AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS

The present invention is directed to novel aminopyrrolidines of formula I, pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compou

INDOLE DERIVATIVES AND DRUGS CONTAINING THE SAME

An indole derivative represented by the following general formula (1) : wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents -(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: Hydroxyindole derivatives

As part of continuing effort to identify novel scaffolds that inhibit the pp60(c-src) protein tyrosine kinase, a series of hydroxyindole amides was rationally designed and synthesized. The most potent derivative was found to bind non-competitively with respect to ATP. (C) 2000 Elsevier Science Ltd. All rights reserved.